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首页> 外文期刊>Disease markers >Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study
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Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study

机译：血清尿酸作为早盘性冠状动脉疾病的存在和严重程度的独立危险因素：一个病例对照研究

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摘要

Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged = 50 years, and 1117 age-and sex-matched apparently healthy people served as controls. The concentrations of UA were measured by uricase method. The severity of CAD was evaluated by Gensini score. The mean serum level of UA was 5.843 +/- 1.479 mg/dl in EOCAD patients and 5.433 +/- 1.529 mg/dl in controls. Serum UA levels were significantly higher in the EOCAD group than those in the control group (P 0 001) and was an independent risk factor for EOCAD (OR = 1.100, 95% CI: 1.022-1.185). The early-onset myocardial infarction patients with 3-vessel disease had higher serum UA levels than those with 1- or 2-vessel disease. The serum UA levels of EOCAD patients with acute coronary syndrome were significantly higher than those with chronic coronary artery disease. EOCAD patients with hyperuricemia had higher Gensini scores than those without hyperuricemia. In addition, the serum UA levels were affected by drinking (P 0 01) and were positively correlated with serum creatinine (r = 0 323) and weight (r = 0 327). Our results show that serum UA was an independent risk factor for EOCAD. The serum UA levels were associated with the presence and severity of EOCAD and suggested that UA may be involved in the progression of EOCAD.
机译：血清尿酸（UA）是人类嘌呤代谢的最终产物。本研究旨在鉴定血清UA和早期发作冠状动脉疾病（EoCAD）之间的潜在关联。该研究人群由1093名年龄≥50岁的EoCAD患者组成，1117名年龄和性别匹配显然是健康的人作为控制。通过尿精方法测量UA的浓度。 CAD的严重程度由Gensini评分评估。 UA的平均血清水平为ECAD患者的5.843 +/- 1.479 mg / dl，控制器中的5.433 +/- 1.529 mg / dl。 ECAD组血清UA水平显着高于对照组（P <0 001）中的水平，并且是EoCAD的独立危险因素（或= 1.100,95％CI：1.022-1.185）。早期患有3艘血管疾病的心肌梗死患者的血清UA水平高于1-或2个血管疾病的血清UA水平。急性冠状动脉综合征患者的血清UA水平显着高于慢性冠状动脉疾病的患者。高尿酸血症患者的患者比没有高尿酸血症的分数更高。此外，血清UA水平受饮用（P <0 01）的影响，并且与血清肌酐（R = 0 323）和重量（R = 0 327）呈正相关。我们的研究结果表明，血清uA是eocad的独立危险因素。血清UA水平与eoCAD的存在和严重程度有关，并提出了UA可能参与eoCAD的进展。

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  • 来源
    《Disease markers》 |2018年第3期|共8页
  • 作者

    Tian Ting-Ting; Li Hui; Chen Sheng-Jie; Wang Qing; Tian Qing-Wu; Zhang Bei-Bei; Zhu Jie; He Guo-Wei; Lun Li-Min; Xuan Chao;

  • 作者单位

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Oslo Univ Hosp Dept Mol Microbiol Oslo Norway;

    Qingdao Univ Affiliated Hosp Dept Sci Res Management Qingdao Peoples R China;

    Acad Med Sci TEDA Int Cardiovasc Hosp Dept Cardiovasc Surg Tianjin Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

    Qingdao Univ Affiliated Hosp Dept Clin Lab Qingdao Peoples R China;

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  • 正文语种 eng
  • 中图分类 病理学;
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