Progress using Tc-99m radiopharmaceuticals for measuring high capacity sites and low density sites

EckelmanW.C.; JonesA.G.; DuattiA.; RebaR.C.

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Progress using Tc-99m radiopharmaceuticals for measuring high capacity sites and low density sites

机译：使用TC-99M放射性药物测量高容量位点和低密度位点的进展

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Technetium-99m (Tc-99m) has long been a mainstay in clinical nuclear medicine, primarily monitoring biological processes in the heart, kidney, liver, and brain. More recently, Tc-99m chelates have been used as the reporter in targeted nuclear medicine probes that monitor changes in specific protein expression products. The strengths remain the inexpensive source of Tc-99m from the Mo-99/Tc-99m generator, its rich chemistry, high-yield kit formulation, and its widespread availability. Hardware and software advances, such as OSEM reconstructions with scatter and attenuation corrections, have led to quantitation of the injected radioactivity in terms of kBq/cm.

机译：Technetium-99m（TC-99m）长期以来一直是临床核医学的主要效力，主要监测心脏，肾脏，肝脏和大脑中的生物过程。最近，TC-99M螯合物已被用作有针对性的核医学探针的记者，其监测特定蛋白表达产品的变化。强度仍然是来自MO-99 / TC-99M发生器的TC-99M的廉价来源，其富含化学，高产套件制剂，以及其广泛的可用性。硬件和软件进步，例如具有散射和衰减校正的OSEM重建，导致在KBQ / CM方面的注入放射性的定量。

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《Drug discovery today》 |2013年第20期|共8页
作者
EckelmanW.C.; JonesA.G.; DuattiA.; RebaR.C.;
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Molecular Tracer LLC Bethesda MD 20814 United States;

Harvard Medical School Boston MA 02115 United States;

University of Ferrara 44121 Ferrara Italy;

NIAID Integrated Research Facility Frederick MD 21702 United States;

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正文语种 eng
中图分类药学;
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Progress using Tc-99m radiopharmaceuticals for measuring high capacity sites and low density sites

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