The suprachoroidal pathways: a new drug delivery route to the back of the eye

Rai Uma Do J. P.; Young Simon A.; Thrimawithana Thilini R.; Abdelkader Hamdy; Alani Adam W. G.; Pierscionek Barbara; Alany Raid G.

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The suprachoroidal pathways: a new drug delivery route to the back of the eye

机译：Suprachoroidal途径：眼睛后部的新药递送途径

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The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.

机译：安全和方便的药物交付策略的开发用于治疗后部眼疾病的挑战性。虽然宫腔内注射患者在临床医生中具有广泛的验收，但其使用与严重的副作用有关。最近，Suprachoroidallapal（SCS）吸引了眼科医生和药物配方蛋白的注意力作为药物给药和输送到眼睛后部的潜在部位。本综述突出了药物递送给后眼部的主要限制，这条途径的SCS和药物递送应用的关键解剖和生理特征，重点是微针以及未来的观点。

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来源
《Drug discovery today》 |2015年第4期|共5页
作者
Rai Uma Do J. P.; Young Simon A.; Thrimawithana Thilini R.; Abdelkader Hamdy; Alani Adam W. G.; Pierscionek Barbara; Alany Raid G.;
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作者单位

RMIT Univ Sch Med Sci Discipline Pharm Bundoora Vic 3083 Australia;

RMIT Univ Sch Med Sci Discipline Pharm Bundoora Vic 3083 Australia;

RMIT Univ Sch Med Sci Discipline Pharm Bundoora Vic 3083 Australia;

Kingston Univ London Fac Sci Comp &

Engn Sch Pharm &

Chem Drug Discovery Delivery &

Patient Care;

Oregon State Univ Coll Pharm Dept Pharmaceut Sci Corvallis OR 97331 USA;

Kingston Univ London Fac Sci Comp &

Engn Sch Pharm &

Chem Drug Discovery Delivery &

Patient Care;

Kingston Univ London Fac Sci Comp &

Engn Sch Pharm &

Chem Drug Discovery Delivery &

Patient Care;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. The suprachoroidal pathways: a new drug delivery route to the back of the eye [J] . Rai Uma Do J. P., Young Simon A., Thrimawithana Thilini R., Drug discovery today . 2015,第4期

机译：脉络膜上的途径：一种新的药物输送途径到眼后
2. The suprachoroidal pathway: a new drug delivery route to the back of the eye [J] . Uma Do J.P. Rai, Simon A. Young, Thilini R. Thrimawithana, Drug discovery today . 2015,第2期

机译：Suprachoroidal途径：眼睛后部的新药物递送途径
3. Suprachoroidal delivery in a rabbit ex vivo eye model: influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes [J] . Edelhauser Henry F., Kadam Rajendra S., Kompella Uday B., Molecular vision . 2013,第2013期

机译：兔离体眼模型中的脉络膜上递送：药物特性的影响，递送的区域差异以及与玻璃体内和前房内途径的比较
4. Hollow Microneedles for Suprachoroidal Drug Delivery to the Posterior Segment of the Eye [C] . Samirkumar R. Patel, Henry F. Edelhuaser, John M. Nickerson, Annual meeting exposition of the Controlled Release Society . 2009

机译：空心微针用于脉络膜上药物递送至眼后段
5. Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system. [D] . Birudaraj, Kondamraj. 2001

机译：经颊药物递送：丁螺环酮和生物粘附性药物递送系统的转运途径的体外表征。
6. Full retraction: Rajendra S. Kadam Jason Williams Puneet Tyagi Henry F. Edelhauser Uday B. Kompella. Suprachoroidal delivery in a rabbit ex vivo eye model: influence of drug properties regional differences in delivery and comparison with intravitreal and intracameral routes. Mol Vis. 2013; 19:1198-1210. [O] . 2019

机译：完全退缩：拉詹德拉·卡丹（Rajendra S. Kadam）杰森·威廉姆斯（Jason Williams）普尼埃·提亚吉（Puneet Tyagi）亨利·F·埃德豪瑟（Henry E.兔离体眼模型中的脉络膜上递送：药物特性的影响递送的区域差异以及与玻璃体内和前房内途径的比较。摩尔视觉2013; 19：1198-1210。
7. Comparison of suprachoroidal drug delivery with subconjunctival and intravitreal routes using noninvasive fluorophotometry. [O] . Puneet Tyagi, Rajendra S Kadam, Uday B Kompella 2012

机译：使用无创荧光光度法比较脉络膜上药物输送与结膜下和玻璃体内途径。
8. Broadly Applicable Nanowafer Drug Delivery System for Treating Eye Injuries. [R] . Pflugfelder, S. C. 2017

机译：广泛适用的Nanowafer药物传递系统治疗眼部损伤。

The suprachoroidal pathways: a new drug delivery route to the back of the eye

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