The roles of ions on bone regeneration

ONeill Edward; Awale Guleid; Daneshmandi Leila; Umerah Obum; Lo Kevin W. -H.

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The roles of ions on bone regeneration

机译：离子对骨再生的作用

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Bone scientists are actively investigating a range of methods to promote skeletal tissue regeneration. A review of recent literature has revealed that several ions are uniquely capable of inducing stem cell differentiation down desired lineages. There exists enormous promise for these ions to be used in bone regenerative medicine. Given that these ions can be released from biodegradable polymeric materials, their long-term delivery can be achieved through a variety of controlled-release strategies compared with the relatively few options available for expensive and fragile polypeptide-based growth factors. In this review, we highlight the developments in using ions in conjunction with biomaterials for bone regeneration.

机译：骨科学家正在积极研究一系列促进骨骼组织再生的方法。对最近的文献的综述表明，几种离子是独特的，能够诱导干细胞分化下所需的谱系。这些离子在骨再生医学中使用了巨大的希望。鉴于这些离子可以从可生物降解的聚合物材料中释放，与相对较少的可用于昂贵和脆弱的基于多肽的生长因子的选择相比，它们的长期递送可以通过各种控制释放策略实现。在本综述中，我们突出了使用离子的开发与骨再生的生物材料结合。

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《Drug discovery today》 |2018年第4期|共12页
作者
ONeill Edward; Awale Guleid; Daneshmandi Leila; Umerah Obum; Lo Kevin W. -H.;
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Univ Connecticut Hlth Ctr Sch Med Inst Regenerat Engn Farmington CT 06030 USA;

Univ Connecticut Hlth Ctr Sch Med Inst Regenerat Engn Farmington CT 06030 USA;

Univ Connecticut Hlth Ctr Sch Med Inst Regenerat Engn Farmington CT 06030 USA;

Univ Connecticut Hlth Ctr Sch Med Inst Regenerat Engn Farmington CT 06030 USA;

Univ Connecticut Hlth Ctr Sch Med Inst Regenerat Engn Farmington CT 06030 USA;

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正文语种 eng
中图分类药学;
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2. Role of organic and ceramic biomaterials on bone healing and regeneration: An experimental study with significant value in translational tissue engineering and regenerative medicine [J] . Ali Moshiri, Neda Tekyieh Maroof, Ali Mohammad Sharifi Iranian Journal of Basic Medical Sciences . 2020,第11期

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4. The Role of Endothelial Cells Differentiated from Bone Marrow Stem Cells in Cartilage and Bone Regeneration [C] . Ho Yun Chung, Eun Jung Oh, Jin Hyun Choi, Asian Symposium on biomedical materials . 2007

机译：内皮细胞与软骨和骨再生中骨髓干细胞分化的作用
5. The role of osteogenic induction in bone tissue engineering and regeneration. [D] . Chaolemeng, Bao. 2016

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6. The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence [O] . Rozalia Dimitriou, George I Mataliotakis, Giorgio Maria Calori, 2012

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机译：与同种异体骨的组合减少了.β - 磷酸钙的早期吸收（.beta.-TCP），增强了作为骨再生支架的作用。大鼠颌骨骨缺损的实验动物研究

The roles of ions on bone regeneration

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