Administration of antioxidants in cancer: debate of the decade

Khurana Rajneet Kaur; Jain Ashay; Jain Atul; Sharma Teenu; Singh Bhupinder; Kesharwani Prashant

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Administration of antioxidants in cancer: debate of the decade

机译：癌症抗氧化剂施用：十年的辩论

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Several randomized clinical trials have divulged that administration of antioxidants during chemotherapy decreases the effectiveness of treatment. Hence, the characteristic feature of this article is extensive assessment of putative benefits and potential risks of natural and synthetic antioxidant supplementation, administered with chemotherapy, based upon the available preclinical and clinical data. After analyzing mixed results, it was concluded that current FDA guidelines should be followed before supplementing antioxidants during cytotoxic treatment. Nevertheless, contradictory experimental animal models opposing human clinical trials discourage the concurrent administration of antioxidants ostensibly owing to the possibility of tumor protection and reduced survival.

机译：几种随机临床试验泄露，化疗过程中抗氧化剂的施用降低了治疗的有效性。因此，本文的特征是基于可用的临床前和临床数据，对具有化疗的天然和合成抗氧化剂补充剂的推定益处和潜在风险的广泛评估。在分析混合结果后，得出结论，在补充细胞毒性治疗期间补充抗氧化剂之前应遵循目前的FDA指南。然而，相反的矛盾实验动物模型反对人类临床试验使抗氧化剂的同时施用抗氧化剂由于肿瘤保护和存活率降低。

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来源
《Drug discovery today》 |2018年第4期|共8页
作者
Khurana Rajneet Kaur; Jain Ashay; Jain Atul; Sharma Teenu; Singh Bhupinder; Kesharwani Prashant;
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作者单位

Panjab Univ UGC Ctr Adv Studies Univ Inst Pharmaceut Sci Chandigarh 160014 India;

Panjab Univ UGC Ctr Excellence Applicat Nanomat Nanomat Nanop Chandigarh 160014 India;

Panjab Univ UGC Ctr Excellence Applicat Nanomat Nanomat Nanop Chandigarh 160014 India;

Panjab Univ UGC Ctr Adv Studies Univ Inst Pharmaceut Sci Chandigarh 160014 India;

Panjab Univ UGC Ctr Adv Studies Univ Inst Pharmaceut Sci Chandigarh 160014 India;

Int Med Univ Dept Pharmaceut Technol Kuala Lumpur Malaysia;

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正文语种 eng
中图分类药学;
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1. Administration of antioxidants in cancer: debate of the decade [J] . Khurana Rajneet Kaur, Jain Ashay, Jain Atul, Drug discovery today . 2018,第4期

机译：癌症抗氧化剂施用：十年的辩论
2. Antioxidants and cancer: a debate on prevention, progression, hormesis,and cruciferous vegetables [J] . Francesco Di Pierro Nutrafoods . 2015,第4期

机译：抗氧化剂和癌症：关于预防，进展，毒物和十字花科蔬菜的辩论
3. Antioxidants and cancer: a debate on prevention, progression, hormesis, and cruciferous vegetables [J] . Francesco Di Pierro Nutrafoods . 2015,第4期

机译：抗氧化剂和癌症：关于预防，进展，毒物和十字花科蔬菜的辩论
4. ASSESSMENT OF SUSTAINED DELIVERY OF ANTIOXIDANTS ON CAOV-3 AND SK-OV-3 OVARIAN CANCER LIKE CELL LINES [C] . Jennifer L. Harpole, Michelle Tucci, Hamed Benghuzzi International ISA biomedical sciences instrumentation symposium;International Society of Automation;Annual Rocky Mountain bioengineering symposium . 2016

机译：CAOV-3和SK-OV-3卵巢癌样细胞系中抗氧化剂持续递送的评估
5. UNITED STATES CIVIL ADMINISTRATION OF THE RYUKYU ISLANDS, 1950-1960: A HISTORICAL ANALYSIS AND APPRAISAL OF A DECADE OF CIVIL ADMINISTRATION OF AN ASIAN AREA. [D] . HEWETT, ROBERT FOSTER, JR. 1966

机译：琉球屿的美国民政管理区，1950-1960年：一个亚洲地区民政管理十年的历史分析和评估。
6. Prospective Randomized Trial on Postoperative Administration of Diet Containing Eicosapentaenoic Acid Docosahexaenoic Acid Gamma-linolenic Acid and Antioxidants in Head and Neck Cancer Surgery Patients with Free-flap Reconstruction [O] . Kiyoaki Tsukahara, Ray Motohashi, Hiroki Sato, 2014

机译：在皮瓣重建术的头颈癌患者中接受含有二十碳五烯酸二十二碳六烯酸γ-亚麻酸和抗氧化剂的饮食术后管理的前瞻性随机试验
7. Over 3 decades of research on dietary flavonoid antioxidants and cancer prevention: What have we achieved? [O] . Hajara H. Alfa, Randolph R. J. Arroo 2019

机译：3多十年的膳食类黄酮抗氧化剂和癌症预防研究：我们达到了什么？
8. Effect of the Supplemental Use of Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cancer. Evidence Report/Technology Assessment Number 75 [R] . Coulter, I., Shekelle, P., Hardy, M., 2003

机译：补充使用抗氧化剂维生素C，维生素E和辅酶Q10对预防和治疗癌症的影响。证据报告/技术评估编号75

Administration of antioxidants in cancer: debate of the decade

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