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首页> 外文期刊>Journal of applied toxicology >Effect-directed identification of endocrine disruptors in plastic baby teethers
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Effect-directed identification of endocrine disruptors in plastic baby teethers

机译：塑料婴儿牙齿内分泌干扰器的效果导向鉴定

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Concerns have been raised regarding the human health effects of endocrine disrupting chemicals (EDCs), many of which are associated with and leaching from plastics. As infants are particularly vulnerable to EDCs, we have investigated whether plastic teethers for babies represent a relevant source of exposure. Applying effect-directed analysis, we use bioassays to screen teethers, toys used to soothe a baby's teething ache, for endocrine activity and chemical analysis to identify the causative compounds. We detected significant endocrine activity in two of 10 plastic teethers. Those samples leached estrogenic and/or antiandrogenic activity as detected in the Yeast Estrogen Screen and Yeast Antiandrogen Screen. After sample fractionation, gas chromatography-mass spectrometry non-target screening revealed that methyl-, ethyl- and propylparaben were responsible for the observed estrogenic and antiandrogenic activity in one product. The second product is likely to contain at least six different antiandrogenic compounds that remain so far unidentified. This study demonstrates that plastic teethers can be a source of infant exposure to well-established and unknown EDCs. Because of their limited value to the product, but potential toxicity, manufacturers should critically revisit the use of parabens in plastic teethers and further toys. Moreover, plastic teethers might leach EDCs that escape routine analysis and, thus, toxicological evaluation. The resulting uncertainty in product safety poses a problem to consumers, producers and regulators that remain to be resolved. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：对内分泌破坏化学品（EDC）的人体健康影响提出了担忧，其中许多是与塑料相关的。由于婴儿特别容易受到EDC，我们研究了婴儿的塑料牙齿是否代表了相关的暴露来源。应用效果导向的分析，我们使用生物测定筛选筛选，用于抚慰婴儿的疼痛的玩具，用于内分泌活动和化学分析以识别致病化合物。我们在10个塑料牙齿中检测到有显着的内分泌活动。这些样品在酵母雌激素筛网和酵母抗抗原筛选中检测到浸出溶解的雌激素和/或抗抗衰性活性。样品分级后，气相色谱 - 质谱非靶筛选显示出甲基 - ，乙基和丙基对羟基甲苯，其负责在一种产品中观察到的雌激素和抗抗衰性活性。第二种产品可能含有至少六种不同的抗抗原化合物，仍然是未识别的。本研究表明，塑料齿齿可以是婴儿暴露于良好和未知的EDC来源。由于其价值有限，但潜在的毒性，制造商应该重视塑料牙齿和其他玩具的使用羟基苯甲酸酯。此外，塑料齿齿可能会脱离常规分析的EDC，因此毒理学评估。由于产品安全的不确定性对仍有待解决的消费者，生产者和监管机构带来了问题。版权所有（c）2015 John Wiley＆Sons，Ltd。

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