...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Dose and Time-Dependent Effects of Cyanide on Thiosulfate Sulfurtransferase, 3-Mercaptopyruvate Sulfurtransferase, and Cystathionine A-Lyase Activities
【24h】

Dose and Time-Dependent Effects of Cyanide on Thiosulfate Sulfurtransferase, 3-Mercaptopyruvate Sulfurtransferase, and Cystathionine A-Lyase Activities

机译：氰化物对硫代硫酸硫酸盐硫磺酸硫代硫酸硫酸硫酸硫酸硫酸硫酸盐和胱硫醚A-Lyase活性的剂量和时间依赖性作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We assessed the dose-dependent effect of potassium cyanide (KCN) on thiosulfate sulfurtransferase (TST), 3-mercaptopyruvate sulfurtransferase (3-MPST), and cystathionine A.-lyase (CST) activities in mice. The time-dependent effect of 0.5 LD50 KCN on cyanide level and cytochrome c oxidase (CCO), TST, 3-MPST, and CST activities was also examined. Furthermore, TST, 3-MPST, and CST activities were measured in stored mice cadavers. Hepatic and renal TST activity increased by 0.5 LD50 KCN but diminished by >2.0 LD50. After 0.5 LD50 KCN, the elevated hepatic cyanide level was accompanied by increased TST, 3-MPST, and CST activities, and CCO inhibition. Elevated renal cyanide level was only accompanied by increased 3-MPST activity. No appreciable change in enzyme activities was observed in mice cadavers. The study concludes that high doses of cyanide exert saturating effects on its detoxification enzymes, indicating their exogenous use during cyanide poisoning. Also, these enzymes are not reliable markers of cyanide poisoning in autopsied samples.
机译：我们评估了氰化钾（KCN）对小鼠硫代硫酸硫酸盐硫酸硫酸盐（TST），3-巯基氟化氢化物硫酸盐酶（3-MPST）的剂量依赖性效果，以及小鼠的胱硫脲A.-Lyase（CST）活性。还研究了0.5Ld50 KCN对氰化物水平和细胞色素C氧化酶（CCO），TST，3-MPST和CST活性的时间依赖性作用。此外，在储存的小鼠尸体中测量TST，3-MPST和CST活性。肝肾TST活性增加0.5Ld50 kcn，但通过> 2.0 ld50减少。在0.5Ld50 KCN之后，肝氰化物水平升高伴有TST，3-MPST和CST活性增加，以及CCO抑制。肾氰化物水平升高仅伴有3MPST活性增加。在小鼠尸体中没有观察到酶活性的明显变化。该研究得出结论，高剂量的氰化物对其排毒酶产生饱和作用，表明它们在氰化物中毒期间的外源性使用。此外，这些酶在尸体杂波样品中是氰化物中毒的可靠标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号