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首页> 外文期刊>Journal of Biomechanics >An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
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An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage

机译：多孔支架对关节软骨再生的实验疲劳研究

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The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress-strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold's pores. (C) 2015 Elsevier Ltd. All rights reserved.
机译：该实验研究的目的是预测植入软骨缺陷中的多孔支架的长期力学行为，用于组织工程目的。通过高度相互连接的孔架构在多己内酯（PCL）支架中最多100,000个无凝结的压缩循环进行疲劳研究。在不同数量的疲劳循环之后已经测量了支架顺应性，应力 - 应变响应和滞后能量，而通过在相同的疲劳时间扫描电子显微镜，通过扫描电子显微镜观察形态。为了模拟支架/组织构建体中的生长组织，支架填充有聚乙烯醇（PVA）的水溶液，并经受重复循环的冷冻和解冻，从而增加水凝胶刚度。疲劳研究表明，机械装载在较少数量的变形循环中引起干支架的失效，而不是将其浸入水中时，并且还有100,000个压缩动态循环不会影响支架/凝胶构建体。这表明了植入骨缺陷中的支架的稳定性，并从植入空脚手架中的机械性能的逼真模拟，以便在脚手架内部的新组织再生。 （c）2015 Elsevier Ltd.保留所有权利。

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