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A computational analysis of nasal vestibule morphologic variabilities on nasal function

机译：鼻腔鼻球体形态变异性的计算分析

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摘要

Although advances in computational modeling have led to increased understanding of nasal airflow, not much is known about the effects of normal sinonasal anatomic variabilities on nasal function. In this study, three distinct variations in the human nasal vestibule airspace that have not been previously described were identified. Computational fluid dynamics modeling of nasal airflow profile in each identified variation of nasal vestibule phenotype was conducted to assess the role of these phenotypes on nasal physiology. Three-dimensional reconstructions of the nasal geometry in sixteen subjects with normal radiographic sinonasal images were created and each respective unilateral nasal cavity was classified as Notched, Standard, or Elongated phenotype based nasal vestibule morphology. Steady state, laminar and incompressible flow simulations were performed in the nasal geometries under physiological, pressure-driven conditions with constant inspiratory pressure. Results showed that at localized regions of the unilateral nasal cavity, average resistance was significantly different among nasal vestibule phenotypes. However, global comparison from nostril to choana showed that average resistance was not significantly different across phenotypes; suggesting that with normal anatomic variations, the nose has a natural compensatory mechanism that modulates localized airflow in order to achieve a desired amount of global airflow. (C) 2016 Elsevier Ltd. All rights reserved.
机译：虽然计算建模的进步导致对鼻气流的了解增加，但对于正常的Sinonasal解剖学变性对鼻功能的影响并不多。在该研究中，鉴定了未来之前未描述的人鼻前庭空隙的三种不同的变化。进行了鼻前型表型各识别的鼻间变异中的鼻气流轮廓的计算流体动力学建模，以评估这些表型对鼻生理学的作用。产生具有正常射线测度的16个受试者的鼻几何形状的三维重建，并且每个相应的单侧鼻腔被归类为缺口，标准或细长表型的基于鼻前庭形态。在生理压力驱动条件下在具有恒定吸气压力的生理压力驱动条件下进行稳态，层流和不可压缩的流量模拟。结果表明，在单侧鼻腔的局部区域，在鼻前庭表型中的平均抗性显着不同。然而，从鼻孔到Choana的全球比较表明，在表型上，平均抗性没有显着差异;建议具有正常的解剖变化，鼻子具有自然补偿机构，其调节局部气流以实现所需量的全局气流。 （c）2016 Elsevier Ltd.保留所有权利。

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