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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The effect of plaster (CaSO4 ·1/2H2O) on the compressive strength, self-setting property, and in vitro bioactivity of silicate-based bone cement.
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The effect of plaster (CaSO4 ·1/2H2O) on the compressive strength, self-setting property, and in vitro bioactivity of silicate-based bone cement.

机译：石膏（CasO4·1 / 2H2O）对硅酸盐基骨水泥的抗压强度，自定位性能和体外生物活性的影响。

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摘要

Bone cements have been widely used for orthopedic applications. Previous studies have shown that calcium silicon-based bone cements (CSC) were injectable, bioactive, biodegradable, and mechanically strong in the long term, while their short-term compressive strength was low and setting time was too long. On the other hand, plaster (CaSO(4)·1/2H(2)O, POP) sets quickly upon contact with water and has excellent short-term compressive strength. The aim of this study is to prepare CSC/POP composite cements and investigate the effect of POP on the compressive strength, setting time, injectability, degradation, and in vitro bioactivity of the composite cements. The results have shown that POP content plays an important role to modulate the physicochemical property of CSC. The addition of POP into CSC significantly decreased the initial and final setting time and enhanced the short-term compressive strength and degradation rate. The obtained composite cement with 30% POP has been found to possess optimal setting time and short-term compressive strength. In addition, the prepared composite cements still maintain apatite-mineralization ability in simulated body fluids and their ionic extracts have no significant cytotoxicity to L929 cells. The results suggested that the addition of POP into CSC is a viable method to improve their setting properties and short-term compressive strength. The obtained composite cements with the optimized composition of 70% CSC and 30% POP could be potentially used for bone repair application.
机译：骨水泥已广泛用于整形外科应用。以前的研究表明，长期以来，硅基骨水泥（CSC）是可注射的，生物活性，可生物降解的和机械强度，而其短期抗压强度低，设定时间太长。另一方面，膏药（Caso（4）·1 / 2h（2）O，POP）在与水接触时快速设置，并且具有出色的短期抗压强度。本研究的目的是准备CSC / POP复合水泥，并研究弹出强度，设定时间，可注射性，降解和复合水泥的体外生物活性的影响。结果表明，流行物含量起到调节CSC的物理化学性质的重要作用。 POP进入CSC的增加显着降低了初始和最终设定时间，并增强了短期抗压强度和降解速率。已获得具有30％POP的所得复合水泥具有最佳设定时间和短期抗压强度。此外，制备的复合水泥仍然保持模拟体液中的磷灰石 - 矿化能力，并且它们的离子提取物对L929细胞没有显着的细胞毒性。结果表明，POP进入CSC是一种改善其设定性能和短期抗压强度的可行方法。所得复合水泥具有70％CSC和30％POP的优化组合物可以潜在地用于骨修复施用。

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