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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The in vivo effect of P-15 coating on early osseointegration
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The in vivo effect of P-15 coating on early osseointegration

机译：P-15涂层对早期骨整合的体内影响

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摘要

The aim of this study was to evaluate mechanically and morphologically the effect of a specific peptide sequence P-15, when incorporated into implant surfaces. Three types of implants were used for the study: Group A: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition. Group B: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition + P-15 incorporation, and as control, Group C: commercially pure titanium implant (blasted and acid etched). After a topographical characterization, transcortical osteotomies were made, and all implant groups (102 implants per group) were randomly placed bilaterally in the tibiae of adult beagle dogs (n = 24). At, 1, 2, and 4 weeks post-surgery, the animals were sacrificed and the samples were retrieved for removal torque tests, for nano indentation, and for histomorphometrical analysis. The results (mean ± 95% CD showed that Group B (34.4 ± 8.7%) presented statistically higher bone-to-implant contact than the other groups (A = 23.9 ± 7.8%; C = 21.7 ± 8.3%) at 1 week, indicating an enhanced osteogenesis due to the peptide incorporation. The results suggested that the incorporation of P-15 to implant surfaces increased its bioactivity and the effects were notable especially in the early stages of the healing process.
机译：本研究的目的是机械和形态地评估特定肽序列P-15的作用，当植入物表面中时。三种类型的植入物用于研究：A组：商业上纯钛植入物（喷砂和酸蚀刻）+电化学薄磷酸钙沉积。 B组：商业上纯钛植入物（喷砂和酸蚀刻）+电化学薄磷酸钙沉积+ P-15掺入，以及作为对照，C组：商业上纯钛植入物（喷砂和酸蚀刻）。在地形表征之后，制备了转瘤截骨瘤，并且所有植入基团（每组102种植入物）随机置于成人比格犬的胫骨中（n = 24）。在手术后，1,2和4周，处死动物，检测样品以用于去除扭矩测试，用于纳米凹口，以及用于组织族分析。结果（平均±95％CD显示B组（34.4±8.7％）呈现统计学上较高的骨对植入接触，比其他组（a = 23.9±7.8％; c = 21.7±8.3％），表明由于肽掺入引起的增强的骨发生。结果表明P-15掺入植入表面增加其生物活性，并且效果特别是在愈合过程的早期阶段。

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