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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >The Relationship Between Greater Prepubertal Adiposity, Subsequent Age of Maturation, and Bone Strength During Adolescence
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The Relationship Between Greater Prepubertal Adiposity, Subsequent Age of Maturation, and Bone Strength During Adolescence

机译：更大的预接种肥胖，随后的成熟年龄与青春期期间的骨强度之间的关系

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This longitudinal study investigated whether greater prepubertal adiposity was associated with subsequent timing of maturation and bone strength during adolescence in 135 girls and 123 boys participating in the Iowa Bone Development Study. Greater adiposity was defined using body mass index (BMI) data at age 8 years to classify participants as overweight (OW, >= 85th percentile for age and sex) or healthy weight (HW). Maturation was defined as the estimated age of peak height velocity (PHV) based on a series of cross-sectional estimates. Measurements were taken at ages 11, 13, 15, and 17 years for estimates of body composition by dual-energy X-ray absorptiometry (DXA), bone compression (bone strength index), and torsion strength (polar strength-strain index) at the radius and tibia by pQCT, and femoral neck bending strength (section modulus) by hip structural analysis. Bone strength in OW versus HW were evaluated by fitting sex-specific linear mixed models that included centered age (visit age - grand mean age of cohort) as the time variable and adjusted for change in fat mass, and limb length in model 1. Analyses were repeated using biological age (visit age - age PHV) as the time variable for model 1 with additional adjustment for lean mass in model 2. BMI was negatively associated with age of maturation (p<0.05). OW versus HW girls had significantly greater bone strength (p<0.001) in model 1, whereas OW versus HW boys had significantly greater bone strength (p<0.001) at the tibia and femoral neck but not radius (p>0.05). Analyses were repeated using biological age, which yielded reduced parameter estimates for girls but similar results for boys (model 1.) Differences were no longer present after adjustment for lean mass (model 2) in girls (p>0.05) whereas differences at the tibia were sustained in boys (p<0.05). These findings demonstrate sex-and site-specific differences in the associations between adiposity, maturation, and bone strength. (C) 2016 American Society for Bone and Mineral Research.
机译：这种纵向研究研究了在135名女孩和参加爱荷华州骨开发研究的青春期和123名男孩的青春期期间的预备脂肪是否与随后的成熟和骨强度的时间相关。使用8年年龄8年来使用体重指数（BMI）数据来定义更大的肥胖，以将参与者作为超重（OW，> = 85百分位为年龄和性别）或健康的体重（HW）。基于一系列横截面估计，成熟被定义为峰高速度（PHV）的估计年龄。通过双能X射线吸收计（DXA），骨压缩（骨强度指数）和扭转强度（极性强度指数）估计体内组合物的估计为13,15和17岁。通过PQCT的半径和胫骨，臀部结构分析通过PQCT和股骨弯曲强度（截面模量）。通过拟合以中心年龄（参观年龄 - 玫瑰师的宏观平均年龄）作为时间变量和调整脂肪质量的变化，并在模型中调整为脂肪质量的变化，评估骨骼强度的骨骼强度使用生物年龄（参观年龄PHV）重复，作为模型1的时间变量，在模型中的贫肿块额外调整2. BMI与成熟年龄负相关（P <0.05）。 op与hw女孩在1型号1中具有明显更大的骨强度（p <0.001），而胫骨和hw男孩在胫骨和股骨颈上具有显着更大的骨强度（p <0.001），但不是半径（p> 0.05）。使用生物学年龄重复分析，从而产生了女孩的减少的参数估计，但在女孩贫血（P> 0.05）调整后，男孩（模型1.）差异不再存在差异（P> 0.05）。胫骨的差异在男孩持续（P <0.05）。这些发现表明了肥胖，成熟和骨骼强度之间的关联性的性别和特异性差异。 （c）2016年美国骨骼和矿物学学会。

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