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首页> 外文期刊>Journal of Cell Communication and Signaling >Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins
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Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins

机译：癌症中的早产蛋白质：专注于分泌的毛细血管相关的蛋白质

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摘要

Tumours are complex entities, wherein cancer cells interact with myriad soluble, insoluble and cell associated factors. These microenvironmental mediators regulate tumour growth, progression and metastasis, and are produced by cancer cells and by stromal components such as fibroblast, adipocytes and immune cells. Through their ability to bind to extracellular matrix proteins, cell surface receptors and growth factors, matricellular proteins enable a dynamic reciprocity between cancer cells and their microenvironment. Hence, matricellular proteins play a critical role in tumour progression by regulating where and when cancer cells are exposed to key growth factors and regulatory proteins. Recent studies suggest that, in addition to altering Wingless (Wnt) signalling, certain members of the Secreted Frizzled Related Protein (sFRP) family are matricellular in nature. In this review, we outline the importance of matricellular proteins in cancer, and discuss how sFRPs may function to both inhibit and promote cancer progression in a context-dependent manner. By considering the matricellular functionality of sFRPs, we may better understand their apparently paradoxical roles in cancers.
机译：肿瘤是复杂的实体，其中癌细胞与多种可溶性，不溶性和细胞相关因子相互作用。这些微环境介质调节肿瘤生长，进展和转移，并通过癌细胞和基质成分，例如成纤维细胞，脂肪细胞和免疫细胞产生。通过它们与细胞外基质蛋白质，细胞表面受体和生长因子结合的能力，Matricellular蛋白能够在癌细胞和它们的微环境之间产生动态互动。因此，原始蛋白质通过调节癌细胞暴露于关键生长因子和调节蛋白，在肿瘤进展中发挥着关键作用。最近的研究表明，除了改变无翼（WNT）的信号传导之外，分泌的细胞混浊的相关蛋白（SFRP）家族的某些成员本质上是原产儿。在这篇综述中，我们概述了癌症在癌症中的重要性，并讨论了SFRPS如何以依赖依赖的方式抑制和促进癌症进展。通过考虑SFRP的雌性功能，我们可以更好地了解他们在癌症中显然的矛盾作用。

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