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A systematic survey on reporting and methods for handling missing participant data for continuous outcomes in randomized controlled trials

机译：关于在随机对照试验中持续成果的缺失参与者数据的报告和方法的系统调查

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Abstract Objective To assess analytic approaches randomized controlled trial (RCT) authors use to address missing participant data (MPD) for patient-important continuous outcomes. Study Design and Setting We conducted a systematic survey of RCTs published in 2014 in the core clinical journals that reported at least one patient-important outcome analyzed as a continuous variable. Results Among 200 studies, 187 (93.5%) trials explicitly reported whether MPD occurred. In the 163 (81.5%) trials that reported the occurrence of MPD, the median and interquartile ranges of the percentage of participants with MPD were 11.4% (2.5%–22.6%).Among the 147 trials in which authors made clear their analytical approach to MPD, the approaches chosen included available data only (109, 67%); mixed-effect models (10, 6.1%); multiple imputation (9, 4.5%); and last observation carried forward (9, 4.5). Of the 163 studies reporting MPD, 16 (9.8%) conducted sensitivity analyses examining the impact of the MPD and (18, 11.1%) discussed the risk of bias associated with MPD. Conclusion RCTs reporting continuous outcomes typically have over 10% of participant data missing. Most RCTs failed to use optimal analytic methods, and very few conducted sensitivity analyses addressing the possible impact of MPD or commented on how MPD might influence risk of bias.
机译：摘要目的评估分析方法随机控制试验（RCT）作者用于解决患者重要的连续结果的缺失参与者数据（MPD）。研究设计和环境我们对2014年发布的RCT的系统调查，核心临床期刊，报告了至少一种分析为连续变量的患者重要结果。结果200项研究中，187名（93.5％）试验明确报告了MPD是否发生。在163名（81.5％）试验中，报告了MPD的发生，中位数和间条件的参与者的参与者百分比的范围为11.4％（2.5％-22.6％）。在作者明确他们的分析方法的147名试验中到MPD，所选择的方法仅包括可用数据（109,67％）;混合效果模型（10,6.1％）;多重估算（9,4.5％）;和最后的观察结转（9,4.5）。在163项研究中，报告MPD，16（9.8％）进行的敏感性分析检查MPD和（18,11％）讨论与MPD相关的偏倚风险的影响。结论RCT报告持续结果通常有超过10％的参与者数据缺失。大多数RCT都未能使用最佳分析方法，并且很少进行敏感性分析，用于解决MPD可能影响的影响或评论MPD如何影响偏见风险。

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