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首页> 外文期刊>Journal of clinical laboratory analysis. >Clinical relevance of peroxisome proliferator‐activated receptor‐γ gene polymorphisms with sepsis
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Clinical relevance of peroxisome proliferator‐activated receptor‐γ gene polymorphisms with sepsis

机译：过氧化物体增殖物激活受体-γ基因多态性与败血症的临床相关性

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摘要

Background Peroxisome proliferator‐activated receptor‐γ ( PPAR γ) is a regulator of inflammation. This study aimed to explore associations between PPAR γ gene single‐nucleotide polymorphisms ( SNP s) and susceptibility to and clinical outcome of sepsis in the North China Han population. Methods This study included 303 patients with sepsis and 303 controls. We conducted genetic typing for 13 common PPAR γ gene SNP s (improved multiplex ligation detection reaction), linkage disequilibrium mapping, and haplotype inference. Associations between SNP genotypes/haplotypes and sepsis susceptibility and outcome (septic shock, organ dysfunction, or death) were assessed using unconditional logistic regression analysis. Results For rs2972164, patients with genotypes CT / CT + TT had higher risk of sepsis than genotype CC (odds ratio [95% CI ]: 1.74 [1.05‐2.86], P ?=?.03 and 1.72 [1.06‐2.80], P ?=?.026, respectively); the T allele was associated with increased sepsis risk compared with the C allele (1.64 [1.04‐2.58], P ?=?.033). For rs1801282, genotypes CG / CG + GG had lower risk of sepsis than genotype CC (0.55 [0.33‐0.92], P ?=?.024 and 0.57 [0.35‐0.95], P ?=?.03, respectively); the G allele was associated with decreased sepsis risk compared with the C allele (0.62 [0.39‐1.01], P ?=?.055). For rs4135275, genotypes AG / AG + GG had higher risk of severe organ dysfunction (multiple organ dysfunction syndrome score 8) than genotype AA (2.66 [1.16‐6.09], P ?=?.038 and 2.21 [1.00‐4.85], P ?=?.042, respectively). Haplotype TAT (rs2972164, rs4684846, and rs17036188) was associated with increased sepsis risk (1.66 [1.03‐2.67], P ?=?.038). Conclusions No mutation was correlated with septic shock or death. PPAR γ gene polymorphisms may play a role in the occurrence and progression of sepsis in the North China Han population.
机译：背景技术过氧化物体增殖物激活受体-γ（PPARγ）是炎症的调节剂。本研究旨在探讨PPARγ基因单核苷酸多态性（SNP S）和北方汉族人群脓毒症遗传率和临床结果的关联。方法本研究包括303例败血症和303例对照。我们进行了13种常见PPARγ基因SNP S（改进的多重连接检测反应），连锁不平衡映射和单倍型推理的遗传键入。使用无条件逻辑回归分析评估SNP基因型/单倍型/单倍型和败血症敏感性和结果（脓疼休克，器官功能障碍或死亡）的关联。结果为RS2972164，基因型CT / CT + TT的患者的败血症风险较高，而不是基因型CC（差异比例[95％CI]：1.74 [1.05-2.86]，P？= 03和1.72 [1.06-2.80]， p？=Δ.026分别）;与C等位基因（1.64 [1.04-2.58]相比，T等位基因与败血症风险增加有关（1.64 [1.04-2.58]，p？= 033）。对于RS1801282，基因型CG / CG + GG的脓毒症风险低于基因型CC（0.55 [0.33-0.92]，P≤X.024和0.57分别）;与C等位基因相比，G等位基因与败血症风险降低有关（0.62 [0.39-1.01]，p？= 055）。对于RS4135275，Genotypes Ag / Ag + GG的严重器官功能障碍风险较高（多器官功能障碍综合征评分＆ 8）比基因型AA（2.66 [1.16-6.09]，P？= 038和2.21 [1.00-4.85] ，p？= 042分别）。单倍型TAT（RS2972164，RS4684846和RS17036188）与败血症风险增加有关（1.66 [1.03-2.67]，P？= 038）。结论没有突变与化粪池休克或死亡相关。 PPARγ基因多态性可能在北方汉族人群中脓毒症的发生和进展中发挥作用。

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  • 作者

    Liu Yu; Wan Wenhui; Fang Fang; Guo Lei; Zhao Yusheng; Zhang Xinghu; Huang Fang;

  • 作者单位

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

    Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing Jiangsu China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    peroxisome proliferator‐activated receptor gamma; polymorphism; prognosis; risk; sepsis; single nucleotide;

    机译：过氧化物体增殖物激活受体γ;多态性;预后;风险;败血症;单核苷酸;

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