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Coinfection with Hepatitis C Virus and HIV

机译：与丙型肝炎病毒和艾滋病毒并发感染

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摘要

Before highly active antiretroviral therapy (HAART) became available, human immunodeficiency virus (HlV)-related morbidity and mortality were so high that they largely overshadowed the potential clinical consequences of coinfection with hepatitis C virus (HCV), the impact of which was often found to be negligible. In the HAART era, the dramatic decrease in AIDS illnesses and mortality brought to light the clinical consequences of chronic HCV infection in HlV-infected patients. It thus appeared that the evolution of chronic HCV infection was worsened by HIV infection, with a risk of faster liver disease progression and a higher risk of cirrhosis, end-stage liver disease, hepatocarcinoma, and, finally, hepatic-related death.
机译：在高活性抗逆转录病毒疗法（HAART）出现之前，与人类免疫缺陷病毒（HlV）相关的发病率和死亡率是如此之高，以至于它们大大掩盖了丙型肝炎病毒（HCV）合并感染的潜在临床后果可以忽略不计。在HAART时代，艾滋病疾病和死亡率的急剧下降使慢性HCV感染在感染HIV的患者中的临床后果更为明显。因此看来，慢性HCV感染的发展因HIV感染而恶化，具有更快的肝病进展风险和更高的肝硬化，终末期肝病，肝癌以及最后与肝有关的死亡的风险。

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