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首页> 外文期刊>Journal of Cytology >Dilemma in diagnosis of pyogenic meningitis in cerebrospinal fluid contaminated with blood: Does leucocyte esterase test help
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Dilemma in diagnosis of pyogenic meningitis in cerebrospinal fluid contaminated with blood: Does leucocyte esterase test help

机译：血液污染脑脊液中皮肤膜炎细菌炎的困境：白细胞酯酶测试有帮助

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Context: Pyogenic meningitis is often a devastating condition which is diagnosed by analysis of cerebrospinal fluid (CSF) obtained by lumbar puncture (LP). CSF thus obtained can get contaminated with peripheral blood leucocytes during LP which renders it unusable for cytological analysis. Leucocyte esterase strips are available for identifying leucocyte esterase activity in urine and other body fluids which suggest inflammation. We conducted this experiment to see whether the leucocyte esterase strip can differentiate between neutrophils invited at the inflammatory site and circulating neutrophils in CSF. Aim: To compare the diagnostic ability of the leucocyte esterase test between pyogenic meningitis and CSF contaminated with circulating neutrophils. Setting and Design: Prospective analytical study conducted in a tertiary care hospital. Materials and Methods: The CSF samples of pyogenic meningitis patients were analyzed for leucocyte esterase activity. The other group was normal CSF which was deliberately contaminated with buffy coat preparation, and leukocyte esterase activity was determined. Statistical Analysis: Diagnostic ability of a test in terms of sensitivity and specificity. Results: Overall sensitivity of the dipsticks in diagnosing pyogenic meningitis is 81% and specificity is 99%. When compared with experimentally contaminated CSF sample, a reading of 2+ on the strip had a sensitivity of 70% and specificity of 100% for pyogenic meningitis. Conclusion: Leucocyte esterase strip is specific for pyogenic meningitis (activated neutrophils), and hence can differentiate from CSF contaminated with blood.
机译：背景：卵晶脑膜炎通常是一种毁灭性的病症，其通过分析通过腰椎穿刺（LP）获得的脑脊液（CSF）诊断。如此获得的CSF可以在LP期间污染外周血白细胞，这使其不具有细胞学分析。白细胞酯酶条可用于鉴定尿液中的白细胞酯酶活性和提出炎症的其他体液。我们进行了该实验，看看白细胞酯酶条是否可以区分在炎症部位和CSF中循环中性粒细胞的中性粒细胞之间的区分。目的：比较循环中性粒细胞污染卵泡性脑膜炎和CSF之间白细胞酯酶测试的诊断能力。设定与设计：在高等教育医院进行预期分析研究。材料和方法：对白细胞酯酶活性分析了卵泡性脑膜炎患者的CSF样本。另一组是正常的CSF，刻意被Buffy涂层制剂污染，测定白细胞酯酶活性。统计分析：在敏感性和特异性方面考验的诊断能力。结果：诊断性脑膜炎诊断时的量敏感性为81％，特异性为99％。与实验污染的CSF样品相比，条带上的2+读数的敏感性为70％，特异性100％，对卵泡性脑膜炎。结论：白细胞酯酶带是特异性脑膜炎（活性中性粒细胞），因此可以区分血液污染的CSF。

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