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首页> 外文期刊>Journal of cutaneous medicine and surgery >Prospective Controlled Trial for the Treatment of Acne Keloidalis Nuchae With a Long-Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet Laser
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Prospective Controlled Trial for the Treatment of Acne Keloidalis Nuchae With a Long-Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet Laser

机译：用长脉冲钕掺杂钇铝石榴石激光治疗痤疮瘢痕疙瘩核糖的前瞻性对照试验

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Background: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with limited interventions of both high efficacy and low morbidity. Objective: To assess the efficacy of the long-pulsed 1064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser and topical steroids as a treatment for AKN compared to topical steroids alone. Methods: We conducted a single-blinded, randomised, within-patient right-left controlled trial (n = 13). Eight monthly laser treatments were performed on the treated half of the scalp, and triamcinolone 0.1% cream was applied to both sides twice daily. Treatment response was measured using a global assessment score (0 to 10). Results: The laser-treated side showed greater improvement in global assessment score. The mean change was ?3.2 (?49.2%) on the treated side and ?2.2 (?32.8%) on the control side ( P = .144). Papules responded well to laser treatment, while larger plaques and nodules showed limited improvement. In the 10 patients with papules only, the difference in improvement between the treated and control sides was statistically significant (mean change was ?3.5 [?59.3%] for the treated side and ?1.8 [?29.5%] for the control side, P = .031). Limitations: This study was limited by a small sample size and a high dropout rate, as well as the lack of a standardised scoring system for AKN. Conclusion: The long-pulsed Nd:YAG laser in conjunction with topical steroids shows promising results in the treatment of AKN, particularly the papular component, and is well tolerated by patients.
机译：背景：痤疮keloidalis nuchae（akn）是一种慢性瘢痕性的毛囊炎，具有高疗效和发病率低的有限干预措施。目的：评估长脉冲1064-nm钕掺杂的钇 - 铝 - 石榴石（Nd：YAG）激光器和局部类固醇作为ANN的处理，与单独的局部类固醇相比AKN的治疗。方法：我们进行单一盲化，随机化，患者内部左右控制试验（n = 13）。在头皮的治疗方法上进行八月激光治疗，每天两次施加Triamcinolone 0.1％乳膏两次。使用全局评估评分（0至10）测量治疗响应。结果：激光治疗方面显示出全球评估评分的提高。平均变化是α3.2（？49.2％）在处理侧，控制侧的α2（？32.8％）（p = .144）。丘疹对激光治疗响应良好，而较大的斑块和结节显示出有限的改善。仅在10名丘疹患者中，治疗和控制侧的改善差异有统计学意义（平均变化是处理的一侧的α3.5[？59.3％]，对照侧的1.8 [〜29.5％] = .031）。局限性：本研究受到小样本尺寸的限制和高辍学率，以及AKN的标准化评分系统。结论：长脉冲Nd：YAG激光结合局部类固醇，表明患AKN，特别是丘疹组分的治疗结果，并通过患者耐受良好的耐受性。

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