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首页> 外文期刊>Journal of Experimental Botany >New insights into the plant epitranscriptome
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New insights into the plant epitranscriptome

机译：新的洞察植物eptrantarceome

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摘要

Throughout all kingdoms of life, ribonucleotides are marked with covalent chemical modifications that change the structure and binding properties of modified RNA molecules. These marks are deposited by 'writer' proteins, recognized by 'readers', and removed by 'erasers', thus forming an epitranscriptomic system of marks and binding proteins directly analogous to the epigenome. Recent advances in marrying classical biochemical techniques with high-throughput sequencing have enabled detailed mapping of plant epitranscriptomic marks, which in turn yielded insights into how these marks regulate a host of biological processes, from shoot stem cell fate to floral transition and from leaf development to viral activity. In this review, we highlight recent developments in the study of plant epitranscriptomics, with an emphasis on N-6-methyladenosine (m(6)A) and 5-methylcytosine (m(5)C). These studies have advanced the field beyond descriptive mapping or isolated genetic studies, and produced a more nuanced understanding of how components of the epitranscriptome and their binding proteins directly regulate critical aspects of plant biology.
机译：在整个王国的所有王国中，核糖核苷酸标记为共价化学修饰，其改变改性RNA分子的结构和结合性质。这些标记由“作家”蛋白质沉积，被“读者”识别，并被“擦除器”除去，从而形成闰族特征组系统的标记和与外观蛋白组合的结合蛋白质。结婚具有高通量测序的经典生化技术的最新进展使得植物闰组痕迹的详细映射，这又产生了这些标记如何调节一系列生物过程，从枝条细胞命运到花卉过渡和叶片开发病毒活动。在本文中，我们突出了植物闰族研究的最新发展，重点是N-6-甲基腺苷（M（6））和5-甲基胞嘧啶（M（5）C）。这些研究已经提出了超出了描述性测绘或分离的遗传研究的领域，并产生了对epitrastcriptome和其结合蛋白的组分直接调节植物生物学的关键方面的更细微的理解。

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