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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Advances in self-assembled chitosan nanomaterials for drug delivery
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Advances in self-assembled chitosan nanomaterials for drug delivery

机译：自组装壳聚糖纳米材料在药物输送中的研究进展

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Nanomaterials based on chitosan have emerged as promising carriers of therapeutic agents for drug delivery due to good biocompatibility, biodegradability, and low toxicity. Chitosan originated nanocarriers have been prepared by mini-emulsion, chemical or ionic gelation, coacervation/precipitation, and spray-drying methods. As alternatives to these traditional fabrication methods, self-assembled chitosan nanomaterials show significant advantages and have received growing scientific attention in recent years. Self-assembly is a spontaneous process by which organized structures with particular functions and properties could be obtained without additional complicated processing or modification steps. In this review, we focus on recent progress in the design, fabrication and physicochemical aspects of chitosan-based self-assembled nanomaterials. Their applications in drug delivery of different therapeutic agents are also discussed in details
机译：由于良好的生物相容性，生物降解性和低毒性，基于壳聚糖的纳米材料已成为有希望的药物输送载体。壳聚糖衍生的纳米载体已通过微乳液，化学或离子凝胶化，凝聚/沉淀和喷雾干燥法制备。自组装壳聚糖纳米材料作为这些传统制造方法的替代品，显示出显着的优势，并且近年来受到越来越多的科学关注。自组装是一个自发的过程，通过该过程，无需额外的复杂处理或修改步骤即可获得具有特定功能和特性的组织结构。在这篇综述中，我们重点研究基于壳聚糖的自组装纳米材料在设计，制造和物理化学方面的最新进展。还详细讨论了它们在不同治疗药物给药中的应用

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