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首页> 外文期刊>Journal of genetics >Changes of host DNA methylation in domestic chickens infected with Salmonella enterica
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Changes of host DNA methylation in domestic chickens infected with Salmonella enterica

机译：用沙门氏菌感染的家用鸡宿主DNA甲基化的变化

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摘要

Cytosine methylation is an effective way to modulate gene transcription. However, very little is known about the epigenetic changes in the host that is infected with Salmonella enterica. In this study, we used methylated DNA immunoprecipitation sequencing to analyse the genomewide DNA methylation changes in domestic chickens after infected with Salmonella. The level of DNA methylation was slightly higher in the genomic regions around the transcription start termination sites in a Salmonella-infected group compared to the controls. Overall, 879 peaks were differentially methylated between Salmonella-infected and control groups, among which 135 were located in the gene promoter regions. Genes including MHC class IV antigen, GABARAPL1, MR1 and KDM1B were shown to be methylated more heavily after infected with Salmonella, whereas DYNLRB2, SEC14L3 and ANKIB1 tended to have fewer methylated cytosine residues in the promoter regions. Gene interaction network analysis of differentially methylated genes in the promoter regions revealed extensive connections with immune-related genes, indicating the possible impact of infection with Salmonella on the epigenetic status of the host.
机译：胞嘧啶甲基化是调节基因转录的有效方法。然而，关于感染沙门氏菌肠道的宿主的表观遗传变化很少。在这项研究中，我们使用甲基化DNA免疫沉淀测序在感染沙门氏菌之后分析家畜的基因组DNA甲基化变化。与对照相比，在沙门氏菌感染的组中的转录开始终止位点周围的基因组区域中DNA甲基化水平略高。总体而言，在沙门氏菌感染和对照组之间，879峰在差异甲基化，其中135位位于基因启动子区域中。包括MHC级抗原，GabaraP1，MR1和KDM1B在内的基因被显示出在用沙门氏菌感染后更加重大甲基化，而DynlRB2，Sec14L3和Ankib1倾向于在启动子区域中具有较少的甲基化胞嘧啶残基。启动子区域中差异甲基化基因的基因相互作用网络分析显示出与免疫相关基因的广泛关系，表明感染与沙门氏菌的可能影响在宿主的表观遗传状态上。

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  • 来源
    《Journal of genetics》 |2017年第4期|共6页
  • 作者

    Wang Fei; Li Jianchao; Li Qinghe; Liu Ranran; Zheng Maiqing; Wang Qiao; Wen Jie; Zhao Guiping;

  • 作者单位

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

    Chinese Acad Agr Sci Inst Anim Sci Beijing 100193 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    Salmonella enterica infection; chicken; DNA methylation;

    机译：沙门氏菌肠道感染;鸡;DNA甲基化;

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