Microtubules and the Protein Tau

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Microtubules and the Protein Tau

机译：微管和蛋白质Tau

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The protein tau is central to the pathological process underlying sporadic AD. It is chiefly a neuronal protein and is produced in all portions of the nervous system (CNS, PNS, ENS) (Trojanowski et al. 1989). In immature nerve cells, tau is distributed diffusely throughout the entire cell, but during cell maturation it converts into a primarily axonal protein. Tau originates in the cell soma's rough endoplasmatic reticulum, it clears all cellular checkpoints for quality control, and, in this fully functional state, is then transferred to the axonal compartment (Lee et al. 2001; Scholz and Mandelkow 2014). In healthy nerve cells, the protein promotes self-assembly of axonal microtubules and stabilizes them (Fig. 4.1a). Together with motor proteins, microtubules are required for anterograde and retrograde transport of substances within the axon.

机译：tau蛋白对于散发性AD的病理过程至关重要。它主要是一种神经元蛋白，并在神经系统的所有部分（CNS，PNS，ENS）产生（Trojanowski等，1989）。在未成熟的神经细胞中，tau散布在整个细胞中，但在细胞成熟期间它会转化为主要的轴突蛋白。 Tau起源于细胞体的粗面内质网，它清除了所有细胞检查点以进行质量控制，然后在这种完全功能的状态下转移到了轴突区室（Lee等人2001; Scholz和Mandelkow 2014）。在健康的神经细胞中，该蛋白质可促进轴突微管的自组装并使其稳定（图4.1a）。与运动蛋白一起，微管对于轴突内物质的顺行和逆行运输是必需的。

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《Advances in anatomy embryology and cell biology.》 |2015年第null期|共4页
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中图分类细胞生物学;
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1. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau [J] . Alejandra del C. Alonso, Inge Grundke-Iqbal, Hector S. Barra Proceedings of the National Academy of Sciences of the United States of America . 1997,第1期

机译：tau蛋白的磷酸化异常和阿尔茨海默氏原纤维神经变性的机制：微管相关蛋白1和2的螯合以及异常tau蛋白对微管的分解
2. Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis [J] . Kenneth J. Rosenberg, Jennifer L. Ross, H. Eric Feinstein, Proceedings of the National Academy of Sciences of the United States of America . 2008,第21期

机译：微管相关tau蛋白的互补二聚化：对微管捆绑和tau介导的发病机制的影响。
3. Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitro. [J] . Riederer IM, Pfulg C, Bouras C, Neuroreport . 2003,第1期

机译：人免疫球蛋白和Fc片段通过tau蛋白促进微管组装，并在体外诱导神经元微管的构象变化。
4. Phosphorylation of microtubule-associated protein tau by mitogen-activated protein kinase in Alzheimer’s disease [C] . Tingting Li, Huahua Shi, Yan Zhao International Conference on Advanced Composite Materials and Manufacturing Engineering . 2018

机译：丝裂膜引起蛋白质促乳丝溶蛋白激酶在阿尔茨海默病中的磷酸化
5. Biological physics studies of microtubules, taxol, and the microtubules-associated protein, tau. [D] . Ross, Jennifer L. 2004

机译：微管紫杉醇和微管相关蛋白tau的生物物理研究。
6. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau [O] . Alejandra del C. Alonso, Inge Grundke-Iqbal, Héctor S. Barra, 1997

机译：tau磷酸化异常和阿尔茨海默氏神经原纤维变性的机制：微管相关蛋白1和2的螯合和异常tau拆解微管
7. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo [O] . M Mercken, I Fischer, KS Kosik, 1995

机译：TAU，微管蛋白和其他微管相关蛋白的三种不同的轴突运输速率：TAU与体内微管的动态相互作用的证据

Microtubules and the Protein Tau

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