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首页> 外文期刊>Journal of Labelled Compounds and Radiopharmaceuticals >[carbonyl- 11C]Benzyl acetate: Automated radiosynthesis via Pd-mediated [ 11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey
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[carbonyl- 11C]Benzyl acetate: Automated radiosynthesis via Pd-mediated [ 11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey

机译：[羰基-11c]苄酯：通过PD介导的[11c]一氧化碳化学和猴子摄取的血氧化物聚集和PET测量

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摘要

[carbonyl- 11C]Benzyl acetate ([ 11C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [ 11C]1 was synthesized from [ 11C]carbon monoxide, iodomethane and benzyl alcohol via palladium-mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in-house developed Labview software. Under production conditions, [ 11C]1 was obtained in 10% (n = 6) decay-corrected radiochemical yield from [ 11C]carbon monoxide in 96% radiochemical purity and with an average specific radioactivity of 2415 mCi/μmol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SUV = 3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain.
机译：[羰基-11c]苄酯（[11c] 1）已提出作为用于将醋酸胶神经胶质代谢成像到谷氨酸和谷氨酰胺的潜在剂，并用正电子发射断层扫描。 通过钯介导的化学从[11C]一氧化碳，碘甲烷和苄醇合成[11C] 1。 通过内部开发的LabVIEW软件控制的改进的Synthia平台，可放热合成自动化。 在生产条件下，从[11C]一氧化碳中的10％（n = 6）衰减的放射化学产率中得到10％（n = 6）的放射性化学产率。96％的放射化学纯度和2415mCi /μmol的平均特异性放射性。 总辐射合成时间约为45分钟。 猴脑（SUV = 3.1）中放射性的峰值吸收相对较高，可享受测量醋酸胶质胶质细胞的摄取和代谢。

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