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首页> 外文期刊>Journal of Korean medical science >Detection of EML4-ALK and other ALK fusion genes in lung cancer: A lesson from the leukemia fusion gene analysis and future application
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Detection of EML4-ALK and other ALK fusion genes in lung cancer: A lesson from the leukemia fusion gene analysis and future application

机译:肺癌中EML4-ALK和其他ALK融合基因的检测:来自白血病融合基因分析的课程和未来应用

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摘要

We read with interest the article "EML4-ALK Fusion Gene in Korean Non-Small CeE Lung Cancer" in a recent issue of the Journal of Korean Medical Science by Jin et al. (1). In this study, EML4-ALK fusion gene was detected in 10 of 167 non-small cell lung cancer (NSCLC) patients by using reverse transcriptase-poly-merase chain reaction (RT-PCR) as a basic screening technique instead of fluorescence in situ hybridization (FISH) method. The frequency of EML4-ALK fusion gene in this study (6.0%) was not largely different from a previous study that used the FISH method on Korean NSCLC patients (4.2%) (2), while it did not diverge from the results in previous studies on a general NSCLC patient population that yielded 3%-7% ratios as well.
机译:我们利息阅读了Jin等人韩国医学科学期刊韩国医学杂志期刊中的“EML4-Alk融合基因”的兴趣。 (1)。 在该研究中,通过使用逆转录酶 - 聚类聚合物链反应(RT-PCR)作为基本筛选技术而不是原位荧光,在167个非小细胞肺癌(NSCLC)患者中检测到EML4-Alk融合基因。 杂交(鱼类)方法。 本研究中的EML4-Alk融合基因的频率(6.0%)与先前的研究没有,使用韩国NSCLC患者的鱼类方法(4.2%)(2),虽然它在前面的结果中没有发散 关于一般性NSCLC患者群体的研究也产生了3%-7%的比率。

著录项

  • 来源
    《Journal of Korean medical science》 |2012年第5期|共2页
  • 作者单位

    Department of Laboratory Medicine School of Medicine Kyung Hee University Seoul South Korea;

    Department of Laboratory Medicine School of Medicine Kyung Hee University Seoul South Korea;

    Department of Laboratory Medicine School of Medicine Kyung Hee University Seoul South Korea;

    Department of Hematology-Oncology School of Medicine Kyung Hee University Seoul South Korea;

    Department of Hematology-Oncology School of Medicine Kyung Hee University Seoul South Korea;

    Green Cross Reference Laboratory Yongin South Korea;

    Institute of Pharmaceutical Biology ZAFES Diagnostic Center of Acute Leukemia Goethe-University;

    Institute of Pharmaceutical Biology ZAFES Diagnostic Center of Acute Leukemia Goethe-University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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