...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Study of CD4+CD8+ Double positive T-lymphocyte phenotype and function in Indian patients infected with HIV-1
【24h】

Study of CD4+CD8+ Double positive T-lymphocyte phenotype and function in Indian patients infected with HIV-1

机译：CD4 + CD8 +双阳性T淋巴细胞表型及其在印度患者HIV-1患者中的研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD4+CD8+ double positive T cells represent a minor peripheral blood lymphocyte population. CD4+ expression on CD8+ T cells is induced following cellular activation, and as chronic HIV-1 infection is associated with generalized immune activation, double positive T cells studies have become necessary to understand the immunopathology of human immunodeficiency virus (HIV). The frequency of double positive T cells in persons infected with HIV was studied in comparison to uninfected controls. Further, the expression of CD38, HLA-DR, and programmed death (PD)-1 on these cells were ascertained. HIV-1 specific double positive T cells were also studied for their cytokine secretory ability and phenotype. A significantly higher double positive cell population was observed in the patients with advanced HIV disease (CD4+ T cell counts below 200cells/μl), as compared to patients with CD4+ T cell counts above 500cells/μl. Double positive T cells from patients with symptomatic HIV disease had a significantly increased activation and exhaustion levels, compared to asymptomatic subjects and to single positive T cells from the same subjects. HIV-1 specific double positive T cells showed further increase in CD38 and PD-1 expression levels. The proportion of CD38 and PD-1 expressing total and HIV-1 specific double positive T cells correlated positively with HIV-1 plasma viremia and negatively with CD4+ T cell counts. HIV infection results in a marked increase of double positive T cell population, and this cell population shows higher level of activation and exhaustion (increased PD-1 expression) compared to the single positive CD4+ and CD8+ T cells.
机译：CD4 + CD8 +双阳性T细胞代表轻微的外周血淋巴细胞群。在细胞活化后诱导CD4 +表达CD8 + T细胞的表达，并且随着慢性HIV-1感染与广义免疫激活相关，对人免疫缺陷病毒（HIV）的免疫病理学有必要进行双阳性T细胞研究。与未感染的对照相比，研究了用艾滋病毒感染的人感染的双阳性T细胞的频率。此外，确定CD38，HLA-DR和编程死亡（PD）-1对这些细胞的表达。还研究了HIV-1特异性双阳性T细胞，用于其细胞因子分泌能力和表型。与500cells /μl高于500cells /μl的CD4 + T细胞计数的患者相比，在高级艾滋病毒疾病（CD4 + T细胞计数以下）中观察到显着更高的双阳性细胞群。与无症状受试者相比，来自症状艾滋病毒疾病患者的双阳性T细胞具有显着增加的活化和耗尽水平，并与来自同一受试者的单一阳性T细胞相比。 HIV-1特异性双阳性T细胞显示CD38和PD-1表达水平进一步增加。 CD38和PD-1表达总和HIV-1特异性双阳性T细胞的比例随着HIV-1血浆病毒血症和CD4 + T细胞计数负相关。 HIV感染导致双阳性T细胞群的显着增加，与单阳性CD4 +和CD8 + T细胞相比，这种细胞群显示出更高水平的活化和耗尽（增加PD-1表达）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号