首页> 外文期刊>Journal of Pharmacological and Toxicological Methods >Evaluation of the sensitivity of a new fully implantable telemetry device and the importance of simultaneously measuring cardiac output and left ventricular pressure.
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Evaluation of the sensitivity of a new fully implantable telemetry device and the importance of simultaneously measuring cardiac output and left ventricular pressure.

机译:评价新型全植入遥测装置的敏感性及同时测量心输出和左心室压力的重要性。

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摘要

KI TU7/T27H implant detects drug-induced CV changes with statistical significance using a standard, four-subject design. The ability of the TU7/T27H to also measure CO and LVP allowed for full characterization of the CV impact of hydralazine and milrinone, which could have been misinterpreted/missed altogether if these drugs were novel and the endpoints evaluated were prospectively limited to the minimum suggested in ICH S7A.
机译:KI TU7 / T27H植入物检测药物诱导的CV变化,使用标准设计,使用标准设计,具有统计学意义。 TU7 / T27H还能够测量CO和LVP的能力,可以全面表征吡嗪和Milrinone的CV影响,如果这些药物是新颖的,可以完全误解/错过,并且评估的终点被潜在潜在限制在建议的最低限度 在ich s7a。

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