Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution

Hines C. D. G.; Song X.; Kuruvilla S.; Farris G.; Markgraf C. G.

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Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution

机译：用Posaconazole IV溶液治疗的成人和少年比格犬大脑中心室系统的磁共振成像评估

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Introduction: Noxafil (R) (posaconazole; POS) is a potent, selective triazole antifungal approved for use in adults as an oral suspension, oral tablet and intravenous (IV) Solution. In support of pediatric administration of POS IV Solution to children < two years of age, a nonclinical study in juvenile pre-weaning Beagle dogs was conducted, which showed enlarged lateral ventricles in the brain at the conclusion of a 6 week dosing period.

机译：简介：Noxafil（R）（posaconazole; POS）是一种有效的选择性三唑抗真菌抗生素，用于成人作为口腔悬浮液，口服片和静脉注射（IV）溶液。为了支持对儿童的儿科局部给予儿童<2岁儿童溶液，进行了少年前后犬犬的非植物研究，在6周给药期结束时，脑中的侧脑室显示出扩大的侧脑室。

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《Journal of Pharmacological and Toxicological Methods》 |2015年第null期|共10页
作者
Hines C. D. G.; Song X.; Kuruvilla S.; Farris G.; Markgraf C. G.;
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作者单位

Merck Res Labs Dept Imaging West Point PA USA;

Merck Res Labs Dept Toxicol Sci West Point PA USA;

Merck Res Labs Dept Pathol West Point PA USA;

Merck Res Labs Dept Imaging West Point PA USA;

Merck Res Labs Discovery Sci Support Kenilworth NJ USA;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Beagle dog; Brain; Brain ventricle; De-risk; Drug discovery; Methods; MRI; Pathology; Posaconazole; Volume;

机译：小猎犬;脑;脑室;虚危险;药物发现;方法;MRI;病理学;posaconazole;体积;

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1. Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution [J] . Hines C. D. G., Song X., Kuruvilla S., Journal of Pharmacological and Toxicological Methods . 2015,第Null期

机译：泊沙康唑IV溶液处理的成年和幼年比格犬脑室的磁共振成像评估
2. Evaluation of left ventricular function with cardiac magnetic resonance imaging and echocardiography after administration of dobutamine and esmolol in healthy beagle dogs [J] . Hyeryoung JEONG, Hanbin LEE, Jaihyun JUNG, The Journal of Veterinary Medical Science . 2021,第4期

机译：左心室功能与心脏磁共振成像和超声心动图施用多巴酚丁胺和Esmolol在健康犬的左心室功能
3. Contrast echocardiography to assess left ventricular volume and function in Beagle dogs: comparison with 3-Tesla dual source parallel cardiac magnetic resonance imaging. [J] . Kim J. H., Lee M. S., Kim S. Y., The Veterinary Journal . 2013,第2期

机译：对比超声心动图评估比格犬的左心室容积和功能：与3-Tesla双源平行心脏磁共振成像的比较。
4. Fully automated assessment of left ventricular volumes and mass from cardiac magnetic resonance images [C] . Marino M., Veronesi F., Corsi C. Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：从心脏磁共振图像全自动评估左心室容积和质量
5. Effects of hypercapnia, hypocapnia and hyperoxemia on brain magnetic resonance images in anesthetized dogs [D] . Rioja Garcia, Eva 2009

机译：高碳酸血症，低碳酸血症和高氧血症对麻醉犬脑磁共振图像的影响
6. Longitudinal Volumetric Assessment of Ventricular Enlargement in Pet Dogs Trained for Functional Magnetic Resonance Imaging (fMRI) Studies [O] . Eva Gunde, Kálmán Czeibert, Anna Gábor, 2020

机译：用于功能磁共振成像（FMRI）研究培训的宠物狗心室扩大的纵向体积评估
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Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution

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