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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Ischemic Stroke in Patients Receiving Aspirin
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Ischemic Stroke in Patients Receiving Aspirin

机译：接受阿司匹林的患者缺血性脑卒中

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Background: The widespread use of aspirin-driven vascular prevention strategies does not impede the occurrence of first and recurrent ischemic strokes in numerous subjects. It is not clear what factors are associated with aspirin failure beyond the functional diagnosis of aspirin resistance in selected subjects. Current management guidelines provide little or no recommendations on the proper strategy for subjects who had a stroke while receiving aspirin. We assessed clinical features of subjects who had a first or recurrent stroke while taking aspirin. Methods: We studied demographic characteristics, vascular risk factors, stroke subtypes, and concomitant medication use in subjects with first or recurrent ischemic strokes. Patients receiving antiplatelet medications other than aspirin and/or oral anticoagulants were excluded from this analysis. Results: Seven hundred and nine patients with first (n = 552) or recurrent (n = 157) ischemic stroke were evaluated. Aspirin was being taken by 29% of first and 48% of recurrent stroke subjects. There was a higher prevalence of hypertension, hypercholesterolemia, and smoking in aspirin users with first and recurrent stroke (P < .05). Diabetes and coronary artery disease were more frequent in aspirin users with first ischemic strokes (P < .003), but not in those who had recurrent ischemic strokes. Aspirin users were more likely to be also receiving statins and antihypertensive drugs (P < .001). Conclusions: Aspirin failure in ischemic stroke prevention may exceed functional resistance to aspirin and could be associated with a higher prevalence of lacunar stroke, comorbidities, and/or adverse interactions with other drugs. These patients may require a different approach regarding prevention strategies.
机译：背景：阿司匹林驱动的血管预防策略的广泛使用不会妨碍许多受试者中的第一和复发性缺血卒中的发生。目前尚不清楚哪种因素与阿司匹林失败相关的因素超出了选定受试者中的阿司匹林抗性的功能诊断。目前的管理指南提供了关于在接受阿司匹林时进行中风的受试者的适当策略的很少或没有建议。我们评估了在服用阿司匹林的患者的受试者的临床特征。方法：我们研究了具有第一或复发性缺血性卒中的受试者的人口统计学特征，血管危险因素，中风亚型和伴随药物。从该分析中排除接受阿司匹林和/或口服抗凝血剂以外的抗血小板药物的患者。结果：评价七百九九患者（n = 552）或复发（n = 157）缺血性卒中患者。阿司匹林在第一和48％的复发性中风受试者中占29％。高血压，高胆固醇血症的患病率较高，并在阿司匹林用户中吸烟，第一和复发中风（P <.05）。阿司匹林用户在具有第一缺血性卒中（P <.003）的糖尿病用户中更频繁地频繁频繁，但在那些具有复发性缺血性卒中的人中也是如此。阿司匹林用户更有可能接受他汀类药物和抗高血压药物（P <.001）。结论：缺血性卒中预防的阿司匹林失效可能超过阿司匹林的功能性，并且可以与其他药物血清中风，组合和/或不良相互作用的患病率较高。这些患者可能需要有关预防策略的不同方法。

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