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首页> 外文期刊>Journal of the advanced practitioner in oncology >Ziv-Aflibercept Use in Metastatic Colorectal Cancer
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Ziv-Aflibercept Use in Metastatic Colorectal Cancer

机译:Ziv-AfliBercept用于转移性结肠直肠癌

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Colorectal cancer (CRC) is the third most common cancer in both men and women (Siegel, Naishad-ham, & Jemal, 2013). In 2011, the global number of newly diagnosed cases worldwide was more than 1 million, with 600,000 deaths worldwide (Jemal et al., 2011). Although incidence and mortality rates in the United States have decreased over time, it is estimated that 102,480 new cases of CRC will be diagnosed in 2013, with 50,830 deaths expected (Siegel et al., 2013). Most cases of CRC arise sporadically; however, some risk factors include age, previous colonic polyps, and inflammatory bowel disease. Environmental factors such as consuming red meat, maintaining a high-fat diet, and smoking can also predispose an individual to CRC. Hereditary syndromes such as Lynch syndrome and familial adeno-matous polyposis are also associated with the development of CRC (Cunningham et al., 2010).
机译:结肠直肠癌(CRC)是男女和女性最常见的癌症(Siegel,Naishad-Ham,&Jemal,2013)。 2011年,全球全球全球新诊断的病例数量超过100万,全球60万人死亡(Jemal等,2011)。 虽然美国的发病率和死亡率随着时间的推移而下降,但估计2013年将诊断102,480例CRC病例,预计50,830人死亡(Siegel等,2013)。 大多数CRC均偶然地出现; 然而,一些风险因素包括年龄,以前的结肠息肉和炎症性肠病。 消耗红肉,维持高脂饮食和吸烟等环境因素也可以使个人能够易于CRC。 植物综合征等遗传综合征和家族性腺体息肉蛋白也与CRC的发展有关(Cunningham等,2010)。

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