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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >A potential electroencephalography and cognitive biosignature for the child behavior checklist-dysregulation profile
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A potential electroencephalography and cognitive biosignature for the child behavior checklist-dysregulation profile

机译：用于儿童行为核对表的潜在脑电图和认知生物关键

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Objective The Child Behavior Checklist-Dysregulation Profile (CBCL/DP) identifies youth at increased risk for significant psychopathology. Although the genetic architecture and several biological correlates of the CBCL/DP have been described, little work has elucidated its underlying neurobiology. We examined the potential utility of electroencephalography (EEG), along with behavioral and cognitive assessments, in differentiating individuals based on the CBCL/DP. Method Participants aged 7 to 14 years of age were categorized into 3 age- and sex-matched groups based on clinical assessment and CBCL/DP: typically developing controls without attention-deficit/hyperactivity disorder (ADHD) (n = 38), individuals with ADHD without the CBCL/DP (ADHD/DP-) (n = 38), and individuals with the CBCL/DP (CBCL/DP+) (n = 38). Groups were compared with EEG and measures of clinical phenomenology and cognition. Results ADHD/DP- and CBCL/DP+ groups had increased inattention, but the CBCL/DP+ group had increased hyperactive/impulsive symptoms, disruptive behavior, mood, and anxiety comorbidities compared with the group with ADHD alone. Cognitive profiles suggested that ADHD/DP-participants had fast impulsive responses, whereas CBCL/DP+ participants were slow and inattentive. On EEG, CBCL/DP+ had a distinct profile of attenuated δ-band and elevated α-band spectral power in the central and parietal regions compared to ADHD/DP- and controls. The low-δ/high-α profile was correlated with measures of emotion and behavior problems and not with inattentive symptomatology or cognitive measures. There were no EEG differences between the ADHD/DP- and control groups. Conclusions An EEG/cognitive profile suggests a distinct pattern of underlying neural dysfunction with the CBCL/DP that might ultimately serve as a biosignature. Further work is required to identify potential relationships with clinically defined psychiatric disorders, particularly those of dysregulated mood.
机译：目标儿童行为核对清单 - 失效概况（CBCL / DP）在增加严重的心理病理学的风险增加时识别青年。虽然已经描述了CBCL / DP的遗传建筑和几种生物相关性，但很少的作品阐明了其潜在的神经生物学。我们检查了脑电图（EEG）以及行为和认知评估的潜在效用，以及基于CBCL / DP的个体。 7至14岁的方法参与者根据临床评估和CBCL / DP分为3个年龄和性匹配的群体：通常在没有注意力/多动障碍（ADHD）（n = 38），个人的情况下发展控制没有Cbcl / DP（ADHD / DP-）（n = 38）的ADHD，以及具有CBCL / DP（CBCL / DP +）（n = 38）的个体。将群体与脑电图和临床现象学和认知的衡量标准进行比较。结果ADHD / DP-和CBCL / DP +组均不吻合，但与单独使用ADHD的组相比，CBCL / DP +组增加了多活性/脉冲症状，破坏性行为，情绪和焦虑症状。认知配置文件表明，ADHD / DP-参与者具有快速冲动的反应，而CBCL / DP +参与者缓慢而疏忽。在EEG，与ADHD / DP和对照相比，CBCL / DP +在中央区域中具有明显的振荡Δ波段和α带谱功率的升高曲线。低δ/高α配置文件与情绪和行为问题的衡量措施相关，而不是含有异常的症状或认知措施。 ADHD / DP和对照组之间没有EEG差异。结论EEG /认知型材表明，具有最终用作生物充分的CBCL / DP的潜在神经功能障碍的明显模式。需要进一步的工作来识别与临床定义的精神病疾病的潜在关系，特别是情绪的心情。

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