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首页> 外文期刊>Journal of Veterinary Research >Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing
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Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing

机译：聚己内酯纳米复合材料的组织病理学评价与骨愈合中的磷酸三钙相比

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Introduction: In recent years, the use of bone scaffolds as bone tissue substitutes, especially the use of such as hydroxyapatite and tricalcium phosphate, has been very popular. Today, the use of modem engineering techniques and advances in nanotechnology have expanded the use of nanomaterials as bone scaffolds for bone tissue applications. Material and Methods: This study was performed on 60 adult male New Zealand rabbits divided into four experimental groups: the control group without any treatment, the second group receiving hydroxyapatite, the third group treated with beta-tricalcium phosphate, and the fourth group receiving nanocomposite polycaprolactone (PCL) scaffold. In a surgical procedure, a defect 6 mm in diameter was made in a hind limb femur. Four indexes were used to assess histopathology, which were union index, spongiosa index, cortex index, and bone marrow. Results: The results showed that nanocomposite PCL and control groups always had the respective highest and lowest values among all the groups at all time intervals. The histopathological assessment demonstrated that the quantity of newly formed lamellar bone in the nanocomposite PCL group was higher than in other groups. Conclusion: All these data suggest that PCL had positive effects on the bone healing process, which could have great potential in tissue engineering and clinical applications.
机译：介绍：近年来，使用骨支架作为骨组织替代品，尤其是使用如羟基磷灰石和磷酸三钙，一直非常流行。如今，使用调制解调器的工程技术和纳米技术的进步已经扩大了纳米材料作为骨组织应用的骨支架。材料和方法：本研究进行了60名成年男性新西兰兔子分为四个实验组：对照组没有任何治疗，第二组接受羟基磷灰石，第三组用β-磷酸钙处理，第四组接受纳米复合材料聚己内酯（PCL）支架。在外科手术中，在后肢股骨中形成直径的6mm缺陷。四个指标用于评估组织病理学，该组织病理学是联合指数，Spongiosa指数，皮质指数和骨髓。结果：结果表明，纳米复合物PCL和对照组在所有时间间隔中总是在所有组中具有相应的最高和最低值。组织病理学评估证明了纳米复合物PCL组中新形成的层状骨的量高于其他基团。结论：所有这些数据表明PCL对骨愈合过程具有积极影响，这可能在组织工程和临床应用中具有很大的潜力。

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