Dr Quinn has written regarding our recent publication in which we describe histopathologic findings in placentas of women with preeclampsia in both early- and late-onset in gestation.1 In our article, we asked, "Is preeclampsia more than one disease?" and found that placentas of women with preeclampsia onset at <34 weeks' gestation were significantly different compared with those with preeclampsia at term. Specifically, we found that vascular lesions and small placental size were related to the diagnosis of preeclampsia earlier in gestation, whereas the predominant finding in women with preeclampsia who received the diagnosis late in the third trimester was increased placental size.
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