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首页> 外文期刊>Allergy >Specific oral tolerance induction in food allergy.
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Specific oral tolerance induction in food allergy.

机译：食物过敏中特定的口服耐受性诱导。

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Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose. Unfortunately, the body of scientific evidence concerning specific oral tolerance induction (SOTI) is still rather poor. Following a couple of case reports, only a few studies on a limited number of patients including different allergens are available. So far, no placebo-controlled, long-term study has been published. Concerning the underlying immunological mechanism, a limited number of studies have reported on changes in antibody production, and more recently on the role of different T-cell populations. The individual pattern of clinical reaction during SOTI seems to vary considerably between patients and from allergen to allergen. Arguments in favour of SOTI are the safety for an inadvertent intake of the offending food and the increased quality of life. Arguments against SOTI are the necessity for a regular intake and possible long-term compliance problems. Indications to consider SOTI in the future might be (i) importance of the incriminated food for the individual nutritional regimen, (ii) avoidance of the corresponding food cannot be assured and (iii) persistent severe food allergy. However, before SOTI can be recommended for the daily praxis, more studies are warranted to clarify whether certain patients may profit from SOTI and to understand the underlying mechanism.
机译：可以通过口服不良食物来诱导食物过敏的特定口服耐受性，从非常低的剂量开始，逐渐将每日剂量增加到等于通常与每日摄入量相关的剂量，然后再增加每日维持剂量。不幸的是，有关特定的口腔耐受诱导（SOTI）的科学证据仍然很差。在收到几例病例报告后，仅针对少数患者（包括不同的过敏原）开展了一些研究。到目前为止，尚未发表安慰剂对照的长期研究。关于潜在的免疫学机制，有限的研究报道了抗体产生的变化，最近还报道了不同T细胞群的作用。 SOTI期间临床反应的个体模式似乎在患者之间以及从过敏原到过敏原之间差异很大。支持SOTI的观点是无意摄入有问题的食物和提高生活质量的安全性。反对SOTI的论点是必须定期摄入和可能的长期合规性问题。将来考虑使用SOTI的迹象可能是（i）所含食物对个体营养方案的重要性，（ii）无法确保避免使用相应食物，以及（iii）持续的严重食物过敏。但是，在可以建议将SOTI用于日常实践之前，需要进行更多的研究以阐明某些患者是否可以从SOTI中受益并了解其潜在机制。

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