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首页> 外文期刊>感染症学雑誌 >Successful treatment with linezolid in two cases of methicillin-resistant Staphylococcus aureus infections in the orthopedic field
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Successful treatment with linezolid in two cases of methicillin-resistant Staphylococcus aureus infections in the orthopedic field

机译：用甲氧西林抗性金黄色葡萄球菌感染的两种情况下成功治疗矫形田

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摘要

We have reported two orthopedic patients with Methicillin-resistant Staphylococcus aureus (MRSA) infections successfully treated with linezolid. The first case was a 64-years-old man with bacteremia, spondylitis and psoas abscesses caused by MRSA. He was treated with arbekacin (ABK) and vancomycin (VCM), and then became afebrile. However he complained of a recurrence of fever and oliguria, we administered linezolid for two weeks intravenously because of fluctuating renal dysfunction. Thereafter his clinical conditions improved. The second case was a 26-years-old man with MRSA infection of the pelvis after a trauma. He was treated with teicoplanin (TEIC) for two weeks. However the minimum inhibiratory concentrations (MICs) of TEIC and VCM against MRSA, isolated from the wounds, were 4 micrograms/ml each, we administered linezolid intravenously and the patient was successfully treated in four weeks. Linezolid has been proven to have high efficacy against MRSA by some trials abroad. But the agent has the indication only for VRE by the Medical Insurance in Japan. These cases also suggest that linezolid is useful for MRSA infections in these cases.
机译：我们报告了两种骨科抗性含有甲氧西林抗性金黄色葡萄球菌（MRSA）感染，用LINZOLID成功处理。第一种案例是64岁的男性，患有MRSA引起的菌血症，脊柱炎和PSOAS脓肿。他被Arbekacin（ABK）和万古霉素（VCM）对待，然后发热。然而，他抱怨发烧和少尿的复发，我们静脉注射了肾上腺素两周，因为肾功能不全波动。此后他的临床条件改善了。第二个案例是一个26岁的男性，在创伤后患有MRSA感染骨盆。他用Teicoplanin（Teic）治疗了两周。然而，从伤口中分离的Teic和VCM的最小抑制浓度（MIC）和对阵MRSA的，每次静脉注射NINOGLID和患者在四周内成功治疗。在国外的一些审判，LINEZOLID已被证明对MRSA具有高效力。但代理商只有日本医疗保险的迹象。这些病例还表明LINEzolid在这些情况下对MRSA感染有用。

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