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首页> 外文期刊>感染症学雑誌 >Two cases of lung infection due to Mycobacterium shimoidei, with special reference to bacteriological investigation
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Two cases of lung infection due to Mycobacterium shimoidei, with special reference to bacteriological investigation

机译：两种肺部感染患者肺病术患者，特别参考细菌调查

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摘要

Mycobacterium shimoidei (Tsukamura 1982) is an uncommon but widely distributed pathogen usually isolated from respiratory specimens. We report two cases of lung disease due to M. shimoidei and the associated bacteriological results. A 45-year-old man (Case 1) admitted to National Hospital Organization (NHO) Miyagi Hospital, a 75-year-old man (Case 2) admitted to NHO Higashi-Hiroshima Medical Center were found in initial chest X-ray and thoracic computed tomography (CT) to have a tuberculosis-like cavity in the left apex (Case 1) and the right apex (Case 2). In Case 1, the patient was treated with isoniazid and rifampicin for one month and lesions showed a partial response. In Case 2, the patient responded favorably with rifampicin, ethambutol, streptomycin, and clarithromycin therapy. Mycobacteria were repeatedly detected in smear and culture from sputum specimens in both patients. Isolates were nonphotochromogenic and rough. Isolated colonies developed after two to three weeks on 2% Ogawa egg medium. Organisms grew on 2% Ogawa egg medium at 30, 37, 42, and 45 degrees C, but not 25 degrees C. Both organisms were susceptible to 500 microg of p-nitrobenzoate per mL and 5mg of sodium chloride per mL. Isolates were negative for niacin accumulation, nitrate reduction, semiquantitative catalase, 68 degrees C catalase, 3-day aryl-sulfatase, iron uptake, and MPB64 antigen production, but positive for Tween 80 hydrolysis (5 and 10 days), acid phosphatase, and pyrazinamidase. Isolates had typical uv-HPLC chromatograms similar to M. shimoidei, demonstrating triple-peak clusters with peaks in the early cluster. 16S rRNA gene sequencing showed isolates to be consistent with Mycobacterium shimoidei. Based on composite characterization, isolates were identified as M. shimoidei. This is, to our knowledge, the third case of M. shimoidei infection reported in Japan.
机译：Shimoidiii（Tsukamura 1982）是一种罕见但广泛分布的病原体，通常是从呼吸样本中分离的。由于M. Shimoidei和相关的细菌结果，我们报告了两种肺病病例。一个45岁的男子（案例1）录取了国家医院组织（NHO）宫城医院，一个75岁的男子（案例2）被录取为NHO HIGASHI-HILOSHIMA MEDICE CENTIRE，在初始胸部X射线和胸部计算的断层扫描（CT）在左侧顶点（壳体1）和右侧顶点（壳体2）中具有结核状腔。在案例1中，患者用异烟肼和利福平处理一个月，病变显示出部分反应。在案例2中，患者对利福平，乙胺醇，链霉素和克拉霉素治疗有利地反应。在两种患者中的痰标本中，反复检测分枝杆菌。分离物是非致力的和粗糙的。在2％Ogawa蛋介质上两到三周后开发的孤立的菌落。有机体在30,37,42和45摄氏度下造成2％的ogawa蛋培养基，但不是25摄氏度，并且两种生物易于每毫升500微米的p-硝基苯甲酸盐和每mL氯化钠。分离物是烟酸积累，硝酸盐还原，半催化剂酶，68℃芳基硫酸酶，铁吸收和MPB64抗原产生的阴性阴性阴性阴性阴性阴性，抗氧化氢糖酶，抗吐素80水解（5和10天），酸性磷酸酶和阳性吡嗪酰胺酶。分离物具有类似于M. Shimoide的典型UV-HPLC色谱图，在早期簇中展示具有峰的三峰簇。 16S RRNA基因测序显示与Shimoidei的分枝杆菌相一致的分离物。基于复合表征，将分离物鉴定为M. Shimoidei。这是我们的知识，日本报告的Shimoidei感染的第三种情况。

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