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首页> 外文期刊>感染症学雑誌 >Pneumonitis with a bronchiolitis obliterans organizing pneumonia-like shadow in a patient with human herpes virus-6 viremia after allogeneic bone marrow transplantation
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Pneumonitis with a bronchiolitis obliterans organizing pneumonia-like shadow in a patient with human herpes virus-6 viremia after allogeneic bone marrow transplantation

机译：肺炎与支气管炎梗死患者在同种异体骨髓移植后组织患者在患有人疱疹病毒-6病毒血症的患者中组织肺炎的阴影

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We report the case of a 42-year-old male who underwent allogeneic bone marrow transplantation (BMT) for acute myelogenous leukemia, and then developed pneumonitis with a bronchiolitis obliterans organizing pneumonia (BOOP)-like shadow. When he came with exertional dyspnea four months after BMT, the chest X-ray and CT findings disclosed bilateral infiltration, and remarkable elevation of his serum KL-6 level, a monitoring marker for disease activity in interstitial lung disease. Although organizing pneumonia (OP) was revealed by a transbronchial lung biopsy, no pathogen was detected in bacterial, fungal and routine viral cultures or by direct cytological examinations using bronchoalveolar lavage (BAL) specimens. Since human herpes virus-6 (HHV-6) was detected in BAL specimens by the polymerase chain reaction (PCR), a diagnosis of a pneumonitis-like BOOP shadow related to HHV-6 was made, and he was treated with methylprednisolone and ganciclovir (GCV). Although there was a relapse of his OP 1.5 months later, with re-elevation of his serum KL-6 level, continuous administration of GCV led to disappearance of HHV-6 in BAL specimens assayed by PCR, in association with normalization of the serum KL-6 level. HHV-6 should be considered as a cause of unexplained pneumonitis in BMT recipients, and KL-6 is useful for monitoring the pneumonitis status in these patients.
机译：我们举报了一个42岁男性接受同种异体骨髓移植（BMT）的42岁男性，用于急性髓性白血病，然后用支气管炎的肺炎梗死组织肺炎（BOOP）的阴影。当他在BMT后四个月到来，胸部X射线和CT调查结果公开了双侧渗透，并且他的血清KL-6水平显着升高，是间质肺病中的疾病活动的监测标志物。虽然组织肺活量（OP）透露横血管肺活检，但在细菌，真菌和常规病毒培养中没有检测到病原体，或者通过支气管肺泡灌洗（BAL）标本进行直接的细胞学检查。由于通过聚合酶链式反应（PCR）在BAL样本中检测到人疱疹病毒-6（HHV-6），因此制备了与HHV-6相关的肺炎状涌影的诊断，并用甲基丙酮和甘昔韦尔治疗（GCV）。虽然他的OP 1.5个月后恢复了他的血清K1-6水平，但连续给予GCV导致PCR在PCR测定的HHV-6中的消失，与血清K1的标准化相关联-6级。 HHV-6应被视为BMT受体中未解释的肺炎的原因，KL-6可用于监测这些患者的肺炎状态。

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