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A case of falciparum malaria successfully treated with intravenous artesunate

机译：用静脉内艺术成功地治疗恶性疟疾的病例

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The case was a 28-year-old Japanese female who was considered to be infected with malaria in India. She manifested fever in Tokyo, Japan, and was brought to Toho University Hospital due to continuous high fever and severe thrombocytopenia. Ring forms at 11% of her RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum diagnosis. Not only the high parasitemia and delay of the diagnosis (6 days after the onset of fever), but also her DIC status required prompt and proper treatment. The diagnosis of severe malaria was strongly considered, and intravenous Artesunate (a qinghaosu derivative) was decided to be administered to the patient. After the four series of administration, mefloquine was subsequently given to prevent recrudescence. Parasite clearance time and fever clearance time were 24 hours and 108 hours, respectively. Thrombocytopenia was improved shortly after the treatment, but then anemia was once worsened with following gradual improvement. No other significant side effects were observed and no recrudescence occurred up to 8 months after her discharge. In Japan, very few cases treated with intravenous Artesunate were reported and our results showed its safe and excellent effect for a Japanese malaria patient.
机译：该案件是一名28岁的日本女性，被认为是在印度的疟疾感染。她表现出在东京，日本的发烧，由于连续高烧和严重的血小板减少症而被带到Toho大学医院。戒指形式的RBCS的11％和ICT疟疾P.F / P.V试验也是疟原虫诊断疟原虫的阳性。不仅高寄生虫和延迟诊断（发烧后6天），而且她的DIC状态要求提示和适当的治疗。强烈考虑严重疟疾的诊断，并决定静脉内春季（Qinghaosu衍生物）给予患者。在四系列施用后，随后给予Mefloquine以防止复发。寄生虫清除时间和发热清除时间分别为24小时和108小时。治疗后不久，血小板减少症在很快得到了改善，但随后贫血症曾经逐渐恶化，逐渐改善。没有观察到其他显着的副作用，并且在出院后没有发生过8个月的复发。在日本，报道了静脉内艺术术治疗的很少病例，我们的结果表明，对日本疟疾患者的安全和优异的效果。

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