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首页> 外文期刊>感染症学雑誌 >Molecular analysis of streptococcal pyrogenic exotoxin genes among group A Streptococcus isolates from Japanese patients with pharyngitis and skin infections
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Molecular analysis of streptococcal pyrogenic exotoxin genes among group A Streptococcus isolates from Japanese patients with pharyngitis and skin infections

机译：咽炎和皮肤感染患者群中链球菌分离株中链球菌热原子毒素基因的分子分析

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Group A Streptococci (GAS) from patients with pharyngitis and skin infections were examined for T serotypes, emm types, and streptococcal pyrogenic exotoxin gene types. The results were summarized as follows: 1) T and emm types were determined in 130 GAS isolates obtained between 2000 and 2004. Among 85 throat isolates, predominant T/emm types were T12/emm12 (25%), T4/emm4 (19%), and T1/emm1 (14%). Among 45 skin isolates, predominant T/emm types were T28/emm28 (13%), TB 3264/emm89 (13%), Tnontypeable/emm58 (13%), T1/emm1 (11%), and T12/emm12 (11%). Predominant T/emm types of skin isolates in 2000-2004 slightly differed from those during 1990s in our previous report. 2) The presence of streptococcal pyrogenic exotoxin genes in 292 GAS isolates obtained between 1990 and 2004 was examined. Significantly lower proportion of skin isolates, compared with throat isolates, was found to harbor the speA gene (12 versus 26%, respectively; p<0.01), or the speC gene (40 versus 65%, respectively; P<0.01). All but one of tested isolates carried the speB gene. The speB-negative isolate was identified as S. dysgalactiae subsp. equisimilis with the group A antigen. 3) Types of the speA alleles were determined in 59 speA-positive GAS isolates. Among 44 throat isolates, 37 (84%) were speA lineage I (speA1-speA2-speA3-speA6), and 7 (16%) were lineage II (speA4-speA5). Among 15 skin isolates, 11 (73%) were lineage I and 4 (27%) were lineage II. The pairwise associations were observed between emm type and speA allele: emm1 and speA2, emm3 and speA3, emm6 and speA4, emm11 and speA2, emm18 and speA1.
机译：检查来自咽炎和皮肤感染患者的一组链球菌（气体）用于T血清型，EMM类型和链球菌发热外毒素基因类型。结果总结如下：1）在2000和2004年之间获得的130个天然气分离株中测定T和EMM类型。在85个咽喉分离物中，主要T / EMM类型为T12 / EMM12（25％），T4 / EMM4（19％） ）和T1 / EMM1（14％）。在45个皮肤分离物中，主要T / EMM类型为T28 / EMM28（13％），TB 3264 / EMM89（13％），TNONITYPERIVE / EMM58（13％），T1 / EMM1（11％）和T12 / EMM12（11 ％）。 2000 - 2004年皮肤分离的主要T / EMM类型与我们之前的报告中的20世纪90年代略有不同。 2）研究了1990和2004年间在1990和2004之间获得的292个气体分离物中的链球菌热原毒素基因的存在。发现与喉部分离物相比的皮肤分离株比例显着降低，发现SPEA基因分别（分别为26％，P <0.01），或SPEN基因分别为40％; P <0.01）。除了测试分离株之外，还具有SPEB基因。 SPEB阴性分离物被鉴定为S. Dysgalactiae亚数据。与抗原组的平衡。 3）在59个SPEA阳性气体分离株中测定SPEA等位基因的类型。在44个咽喉分离物中，37个（84％）是Spea谱系I（Spea1-Spea2-Spea3-Spea6），7（16％）是血管II（Spea4-Spea5）。在15个皮肤分离物中，11（73％）是血线I和4（27％）是血线II。在EMM型和SPEA等位基因：EMM1和SPEA2，EMM3和SPEA3，EMM6和SPEA4，EMM11和SPEA2，EMM18和SPEA1之间观察到成对缔合。

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