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首页> 外文期刊>感染症学雑誌 >The first report of an epidemic of human metapneumovirus infection in Japan: clinical and epidemiological study
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The first report of an epidemic of human metapneumovirus infection in Japan: clinical and epidemiological study

机译：日本人类孢子虫病毒流行病的第一报告：临床和流行病学研究

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Human metapneumovirus (hMPV) was newly discovered as a pathogen in 2001 and is thought to be associated with respiratory disease. To elucidate the prevalence and clinical significance of hMPV among children, we investigated the positive cases of hMPV-RNA by reverse transcription-polymerase chain reaction (RT-PCR) in their nasopharyngeal specimens collected from January to August 2003 in Hiroshima Prefecture, Japan. Our prospective study revealed 77 hMPV-positive cases among 377 children with acute respiratory diseases. Clinical diagnoses of 77 hMPV-positive cases were as follows; bronchitis (33.8%), pneumonia (24.7%), acute respiratory illness (19.5%), asthmatic bronchitis (11.7%) and bronchiolitis (5.2%). The most common symptoms were cough (97.4%), high fever (94.8%) and rhinorrhea (76.6%). Most of the hMPV-positive cases were identified in the spring (between March and May), indicating the presence of an epidemic of hMPV infection in Hiroshima Prefecture. Phylogenetic analysis of the amplified F gene of hMPV isolates revealed that hMPV strains were divided into two genotypes and that their simultaneous circulation occurred within the same epidemic area of Hiroshima Prefecture.
机译：人体孢子虫（HMPV）在2001年新发现为病原体，被认为与呼吸系统疾病有关。为了阐明儿童中HMPV的患病率和临床意义，我们在日本广岛县的2003年1月至2003年8月收集的鼻咽标本中逆转录 - 聚合酶链反应（RT-PCR）研究了HMPV-RNA的阳性病例。我们的前瞻性研究显示了377例急性呼吸疾病的377名儿童HMPV阳性病例。 77 HMPV阳性病例的临床诊断如下;支气管炎（33.8％），肺炎（24.7％），急性呼吸疾病（19.5％），哮喘支气管炎（11.7％）和支气管炎（5.2％）。最常见的症状咳嗽（97.4％），高烧（94.8％）和鼻子（76.6％）。大多数HMPV阳性病例在春季（3月至5月）中鉴定出来，表明广岛县的HMPV感染流行病。 HMPV分离物的扩增F基因的系统发育分析显示，HMPV菌株分为两种基因型，并在广岛县的同一流行区域内发生它们的同时循环。

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