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首页> 外文期刊>藥學雜誌 >Possibility of interactions between prescription drugs and OTC drugs (2nd report)--interaction between levodopa preparation and OTC Kampo medicines for upset stomach
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Possibility of interactions between prescription drugs and OTC drugs (2nd report)--interaction between levodopa preparation and OTC Kampo medicines for upset stomach

机译：处方药与OTC药物（第2次报告）之间的相互作用的可能性 - 左司盆地制剂与OTC Kampo药物的胃部不适

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Our series of studies aimed to examine the possibility of interactions between prescription drugs and over-the-counter (OTC) drugs by monitoring plasma drug concentrations in rats. When a levodopa preparation indicated for patients with Parkinson's disease was administered in combination with Takeda Kampo Ichoyaku K-matsu (A), Taisho Kampo Ichoyaku (B), or Kanebo Kampo Ichoyaku H(C), which are OTC kampo medicines for upset stomach, the plasma levodopa concentration-time curves were shifted downward and the AUC for levodopa was significantly lowered. These results indicate that there may be some interactions between the levodopa preparation and these OTC kampo medicines when ingested together, which leads to a reduction in the bioavailability of levodopa. On the other hand, concomitant administration of the levodopa preparation with Takeda Kampo Ichoyaku A-matsu (D) did not alter any of the pharmacokinetic parameters for levodopa. According to the package inserts for the OTC kampo medicines, A, B and C,but not D, contain metallic additives, such as aluminum silicate and magnesium stearate. In addition, combination with a kampo basis of D (Koshaheiisan-ka-shakuyaku) showed no detectable change in levodopa bioavailability. From these results, it was concluded that metallic additives may play an essential role in generating the drug-interaction between levodopa preparation and OTC kampo medicine for upset stomach.
机译：我们的一系列研究旨在通过监测大鼠的血浆药物浓度来检查处方药和柜台上（OTC）药物之间相互作用的可能性。当帕金森病患者的左旋多巴制剂与Takeda Kampo Ichoyaku K-Matsu（A）组合给药时，Taisho Kampo Ichoyaku（B），或Kanebo Kampo Ichoyaku H（c），这是OTC Kampo Medicines for Fream胃，血浆左旋多巴浓度 - 时间曲线向下移动，左旋多巴的AUC显着降低。这些结果表明，在摄入一起左旋多巴制剂和这些OTC kampo药物之间可能存在一些相互作用，这导致左旋多巴的生物利用度降低。另一方面，伴随着用Takeda Kampo Ichoyaku A-Matsu（d）的左旋多巴制剂没有改变左旋多巴的任何药代动力学参数。根据OTC Kampo药物的包装插入，A，B和C，但不是D，含有金属添加剂，例如硅酸铝和硬脂酸镁。此外，与D（Koshaheiisan-Ka-Shakuyaku）的​​Kampo基础的组合显示，左旋多巴生物利用度没有可检测到的变化。从这些结果来看，得出结论是，金属添加剂可能在产生左司对胃部的药物相互作用和OTC kampo药物的生育胃之间的药物相互作用中起重要作用。

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