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首页> 外文期刊>American Journal of Physiology >GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors.
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GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors.

机译：内毒素注射诱导的GH不敏感与肝脏GH受体减少有关。

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摘要

Sepsis induces a state of growth hormone (GH) resistance associated with a decrease of circulating insulin-like growth factor (IGF) I, a GH-dependent anabolic hormone mainly produced by the liver. To address the mechanisms that might trigger GH insensitivity in sepsis, we investigated the regulation of liver GH receptor (GHR) and its gene expression by endotoxin. Endotoxin injection in rats decreased serum IGF-I and liver GH-binding sites after 10 h. In contrast to liver GHR, circulating GH-binding protein (GHBP) levels were not significantly reduced after endotoxin injection. The parallel decrease in IGF-I and GHR and in their corresponding liver mRNAs suggests that decreased serum IGF-I and liver GHR were likely to result from decreased liver synthesis. Although GH administration in control animals significantly enhanced serum IGF-I, it did fail to prevent the decline in serum IGF-I and liver GH-binding sites in endotoxemic rats. In this study, we showed that endotoxin injection induces a state of GH insensitivity associated with decreased liver GHR. This decline in GHR, which cannot be prevented by exogenous GH, might contribute to the GH insensitivity observed in sepsis.
机译：脓毒症诱导了一种与循环胰岛素样生长因子（IGF）I减少相关的生长激素（GH）抗性状态，IGF I是主要由肝脏产生的GH依赖的合成代谢激素。为了解决可能导致败血症中GH不敏感的机制，我们研究了内毒素对肝脏GH受体（GHR）及其基因表达的调节。大鼠内毒素注射10小时后可降低血清IGF-1和肝脏GH结合位点。与肝脏GHR相反，内毒素注射后循环GH结合蛋白（GHBP）的水平并未显着降低。 IGF-I和GHR及其相应的肝脏mRNA的平行下降表明，血清IGF-I和肝脏GHR下降的原因很可能是肝脏合成下降。尽管在对照动物中施用GH显着增强了血清IGF-I，但它的确不能阻止内毒素血症大鼠血清IGF-I和肝脏GH结合位点的下降。在这项研究中，我们表明内毒素注射诱导了与肝GHR降低相关的GH不敏感状态。 GHR的这种下降（外源性GH无法阻止）可能导致败血症中观察到的GH不敏感。

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