Crystal Structure of Diol Dehydratase Reveals a New Mode of B_(12) Binding and the Mechanism of Activation.

Shibata N.author_name/

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Crystal Structure of Diol Dehydratase Reveals a New Mode of B_(12) Binding and the Mechanism of Activation.

机译：二醇脱水酶的晶体结构揭示了一种新的B_（12）结合和活化机制的新模式。

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Diol dehydratase is an adenosylcobalamin-dependant enzyme that catalyzes conversion from 1,2-diol compounds to corresponding aldehydes. The crystal structure of the enzyme shows that B12 compounds are incorporated with the DBI-on mode. The enzyme has a potassium ion at the active site, where the substrate coordinates to it. The structure of the enzyme complexed with adeninylpentylcobalamin reveals the activation mechanism of adenosylcobalamin.

机译：二醇脱水酶是一种腺苷钴胺酰胺依赖性酶，其催化从1,2-二醇化合物转化为相应的醛。酶的晶体结构表明，B12化合物掺入DBI-on模式。酶在活性位点处具有钾离子，其中基材与其坐标。与腺嘌呤戊基钴胺络合的酶的结构揭示了腺苷钴胺的活化机制。

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《日本结晶学会志》 |2000年第4期|共7页
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Shibata N.author_name/;
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Project Leader Animal Health and Welfare Cheshire County Council;

Project Leader Animal Health and Welfare Cheshire County Council;

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1. Crystal Structure of Diol Dehydratase Reveals a New Mode of B_(12) Binding and the Mechanism of Activation. [J] . Shibata N.author_name/ 日本结晶学会志 . 2000,第4期

机译：二醇脱水酶的晶体结构揭示了一种新的B_（12）结合和活化机制的新模式。
2. Radical catalysis of B_(12) enzymes: structure, mechanism, inactivation, and reactivation of diol and glycerol dehydratases [J] . T. Toraya Cellular and molecular life sciences: CMLS . 2000,第1期

机译：B_（12）酶的自由基催化：二醇和甘油脱水酶的结构，机理，失活和再活化
3. Catalytic roles of the metal ion in the substrate-binding site of coenzyme B_(12)-dependent diol dehydratase [J] . Kamachi T., Doitomi K., Takahata M., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2011,第7期

机译：金属离子在辅酶B_（12）依赖性二醇脱水酶底物结合位点的催化作用
4. ELECTRON MICROSCOPY AND MOeSSBAUER STUDIES OF THE MICROSTRUCTURE IN THE NANOCRYSTALLINE Fe_(74)Cu_1Nb_3Si_(12)B_(10) ALLOY [C] . J. OLSZEWSKI, J. ZBROSZCZYK, W. CIURZYNSKA, Conference on applied crystallography . 2001

机译：电子显微镜和Moessbauer在纳米晶Fe_（74）Cu_1NB_3SI_（12）B_（10）合金中的微观结构研究
5. The Structures of Biofilm-Controlling Proteins from Acinetobacter baumannii and Bacillus subtilis Reveal Details of DNA-binding Mechanisms and Illuminate Potential Therapeutic Targets. [D] . Draughn, George Logan. 2017

机译：鲍曼不动杆菌和枯草芽孢杆菌的生物膜控制蛋白的结构揭示了DNA结合机制的细节，并阐明了潜在的治疗靶标。
6. Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination [O] . Claudine Bisson, K. Linda Britton, Svetlana E. Sedelnikova, -1

机译：晶体结构表明咪唑甘油磷酸脱水酶的反应机理是通过切换Mn（II）配位控制的。
7. A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase [O] . Shibata Naoki, Masuda Jun, Tobimatsu Takamasa, 1999

机译：B12结合和钾离子直接参与酶催化的新模式：二醇脱水酶的X射线结构

Crystal Structure of Diol Dehydratase Reveals a New Mode of B_(12) Binding and the Mechanism of Activation.

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