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首页> 外文期刊>American Journal of Physiology >In vivo downregulation of protein synthesis in the snail Helix apersa during estivation.
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In vivo downregulation of protein synthesis in the snail Helix apersa during estivation.

机译：蜗牛在螺旋过程中体内蛋白质合成的下调。

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摘要

Protein synthesis is downregulated during metabolic depression in a number of systems where the metabolic depression is effected by obvious extrinsic cues. The metabolic depression of the estivating land snail Helix apersa occurs in the absence of any obvious physiological stress and has an intrinsic component independent of temperature, pH, O(2) status, or osmolality. We show that this metabolic depression is accompanied by a downregulation of protein synthesis in vivo. The rate of protein synthesis decreases in two major tissues during estivation: to 23% and 53% of the awake rate in hepatopancreas and foot muscle, respectively. We show from calculations of the theoretical contribution of protein synthesis to total O(2) consumption that the depression of protein synthesis must be a significant, obligate, in vivo component of metabolic depression in H. aspersa.
机译：在许多系统中，通过明显的外在信号影响代谢抑制，在代谢抑制过程中蛋白质合成被下调。耕地蜗牛螺旋apersa的代谢抑制发生在没有任何明显的生理压力的情况下，并且其固有成分与温度，pH，O（2）状态或重量摩尔渗透压浓度无关。我们显示这种代谢抑制伴随着体内蛋白质合成的下调。在培养过程中，两个主要组织的蛋白质合成速率下降：肝胰腺和足部肌肉的清醒率分别降低到23％和53％。我们从蛋白质合成对总O（2）消耗的理论贡献的计算中显示，蛋白质合成的抑制必须是H. aspersa代谢抑制的重要的，专性的，体内成分。

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