• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Mechanisms used to dispose of progressively increasing alkali load in rats.
【24h】

Mechanisms used to dispose of progressively increasing alkali load in rats.

机译：用于处理大鼠逐渐增加的碱负荷的机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our objective was to describe the process of alkali disposal in rats. Balance studies were performed while incremental loads of alkali were given to rats fed a low-alkali diet or their usual alkaline ash diet. Control groups received equimolar NaCl or KCl. Virtually all of the alkali was eliminated within 24 h when the dose exceeded 750 micromol. The most sensitive response to alkali input was a decline in the excretion of NH(4)(+). The next level of response was to increase the excretion of unmeasured anions; this rise was quantitatively the most important process in eliminating alkali. The maximum excretion of citrate was approximately 70% of its filtered load. An even higher alkali load augmented the excretion of 2-oxoglutarate to >400% of its filtered load. Only with the largest alkali load did bicarbonaturia become quantitatively important. We conclude that renal mechanisms eliminate alkali while minimizing bicarbonaturia. This provides a way of limiting changes in urine pH without sacrificing acid-base balance, a process that might lessen the risk of kidney stone formation.
机译：我们的目的是描述大鼠中碱的处置过程。平衡研究是在给低碱饮食或普通碱灰饮食的大鼠增加碱负荷的同时进行的。对照组接受等摩尔的NaCl或KCl。当剂量超过750微摩尔时，几乎在24小时内消除了所有碱。对碱输入最敏感的反应是NH（4）（+）的排泄下降。下一个响应水平是增加未测阴离子的排泄。从数量上说，这种上升是消除碱的最重要过程。柠檬酸盐的最大排泄量约为其过滤负荷的70％。更高的碱负荷会将2-氧戊二酸的排泄量增加至其过滤负荷的> 400％。只有在碱负荷最大的情况下，双碳酸氢盐才在定量上变得重要。我们得出的结论是，肾脏机制消除了碱，同时最大程度地减少了双碳尿症。这提供了一种在不牺牲酸碱平衡的情况下限制尿液pH值变化的方法，该方法可以减少肾结石形成的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号