Letter to the Editor

KeppelHesselinkJ.M.; KopskyD.J.

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Letter to the Editor

机译：给编辑的信

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With great interest we read the paper by Kang et al on the analgesic effects of keta-mine infusion therapy in Korean patients with neuropathic pain.Since 1994, various articles based on case reports, pilot studies, and clinical trials have documented the value and tolerability of ketamine for the treatment of neuropathic pain states.Due to its unique mechanism of action, ketamine is a highly interesting drug for treatment-resistant neuropathic pain syndromes, administered via various routes. Long periods of decreased pain can be triggered by relatively short courses of infusion. Dutch anesthesiologists found that complex regional pain syndrome type 1 (CRPS-1) patients with severe pain treated for 4 days with a continuous infusion of low-dose S-ketamine (N = 30) had a clinically relevant and statistically significant reduction in pain lasting for up to 11 weeks compared with patients receiving placebo (P < 0.001). However, one of the troublesome clinical aspects of treatment using intravenous ketamine is the reemergence of pain after some weeks and, therefore, the necessity to readminister treatment.

机译：我们非常有兴趣地阅读了Kang等人的论文，探讨了Keta-mine输注疗法对韩国神经性疼痛患者的镇痛作用.1994年以来，基于病例报告，先导研究和临床试验的各种文章已证明其价值和耐受性由于其独特的作用机制，氯胺酮是治疗耐药性神经性疼痛综合征的一种非常有趣的药物，可通过多种途径给药。相对较短的输注过程可引起长时间的疼痛减轻。荷兰麻醉学家发现，连续输注低剂量S-氯胺酮（N = 30）治疗4天的重度疼痛的1型复杂局部疼痛综合征（CRPS-1）患者在临床上具有统计学意义，并且统计学上显着减轻了疼痛与接受安慰剂的患者相比，治疗时间长达11周（P <0.001）。然而，使用静脉内氯胺酮治疗的麻烦临床方面之一是几周后疼痛再次出现，因此有必要重新进行治疗。

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《Current therapeutic research, clinical and experimental.》 |2010年第6期|共2页
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KeppelHesselinkJ.M.; KopskyD.J.;
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正文语种 eng
中图分类治疗学;
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6. Letter to the Editors: Concerning Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state by Takashi et al. and Letter to the Editors by Ortolano et al. [O] . Anne Schänzer, Kerstin Giese, Lara Viergutz, 2017

机译：致编辑的信：Takashi等人有关α-葡萄糖苷酶替代疗法在有症状或症状前状态下接受治疗的两个婴儿发作的庞贝病兄弟姐妹中的不同临床结果。和Ortolano等人写给编辑的信。
7. Letter to the Editors: Concerning “Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state” by Takashi et al. and Letter to the Editors by Ortolano et al. [O] . Anne Schänzer, Kerstin Giese, Lara Viergutz, 2017

机译：致编辑的信：关于“在症状性或症状前状态下治疗的婴儿期发作的pompe病的两个兄弟姐妹中α-葡萄糖苷酶替代治疗的不同临床结果”，Takashi等人。和Ortolano等人给编辑的信。

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