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摘要

We would like to thank Dr. Liang and colleagues for the interest they devoted to our study and for their astute comments regarding it.Aging affects the pharmacokinetics and pharmacodynamics of local anesthetics. Concerns with the geriatric patients regarding the administration of regional anesthesia are mostly increased sensitivity to local anesthetics, higher level of block, greater degree of hypotension, and bradycardia even with doses similar to those in younger adults.1 The positive correlation between age and the extent of spread of analgesia has been shown in several studies.
机译:我们要感谢Liang博士及其同事对研究的兴趣和对此研究的敏锐评论。衰老会影响局部麻醉药的药代动力学和药效学。与老年患者有关的区域麻醉的关注主要是对局部麻醉药的敏感性增加,阻塞水平更高,低血压程度更高以及心动过缓,即使其剂量与年轻人相似,也是如此。1年龄与程度的正相关在几项研究中显示了镇痛作用的缓解。

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