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Microvascular adaptations in response to high intensity interval training in skeletal muscle

机译:骨骼肌高强度间隔训练的微血管适应

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Structural and functional changes in skeletal muscle (SM) microvessels play an important role in the pathogenesis of insulin resistance and hypertension. Nitric oxide (NO) bioavailability influences both microvascular density and function. NO bioavailability is determined by its synthesis via endothelial nitric oxide synthase (eNOS), and scavenging through NAD (P)H-oxidase (N0X2) mediated generation of superoxide. High intensity interval training (HIT) elicits similar metabolic and macrovascular adaptations to endurance training (ET). However, its effects on the SM microvasculature have not been investigated. We therefore aimed to see if HIT elicited similar changes in capillary density and microvascular endothelial enzyme content to ET.
机译:骨骼肌(SM)微血管的结构和功能变化在胰岛素抵抗和高血压发病机制中起重要作用。 一氧化氮(NO)生物利用度影响微血管密度和功能。 没有通过内皮一氧化氮合酶(eNOS)的合成来决定生物利用度,并通过NAD(P)H-氧化酶(N0×2)介导的超氧化物的介导。 高强度间隔训练(命中)引发类似的代谢和大血管适应耐力训练(ET)。 然而,它没有研究其对SM微血管结构的影响。 因此,我们旨在了解毛细血管密度和微血管内皮酶含量的引发相似的类似变化。

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