• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons >C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: correlation with histologic findings.
【24h】

C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: correlation with histologic findings.

机译：ABO和HLA不相容的肾同种异体移植活检中的C4d和C3d染色：与组织学结果相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biopsies of ABO-incompatible and positive crossmatch (HLA-incompatible) renal allografts were retrospectively examined to compare results of C4d and C3d staining, and the correlation between such staining and histologic findings suggestive of antibody-mediated rejection (AMR). A total of 75 biopsies (55 protocol, 17 for graft dysfunction, 3 for other indications) of 24 ABO-incompatible grafts and 244 biopsies (103 protocol, 129 for graft dysfunction, 12 for other indications) of 66 HLA-incompatible grafts were examined; all were stained for C4d and approximately 40% for C3d. In ABO-incompatible grafts, 80% of protocol biopsies and 59% performed for graft dysfunction showed C4d staining in peritubular capillaries (PTC); this staining was not correlated with neutrophil margination in PTC. In HLA-incompatible grafts, PTC C4d was present in 26% of protocol biopsies and 60% of biopsies for graft dysfunction; 92% of biopsies with >1+ (0-4+ scale), diffuse PTC C4d had > or =1+ margination and/or thrombotic microangiopathy (TMA), compared with 12% of C4d-negative biopsies. C3d was somewhat more predictive of margination than C4d in ABO-incompatible, but not HLA-incompatible, grafts. In summary, while PTC C4d deposition indicates probable AMR in biopsies of HLA-incompatible grafts, including protocol biopsies, there is no histologic evidence that C4d deposition is correlated with injury in most ABO-incompatible grafts.
机译：回顾性检查ABO不兼容和阳性交叉匹配（HLA不兼容）肾同种异体的活检，以比较C4d和C3d染色的结果，以及这种染色与表明抗体介导排斥（AMR）的组织学发现之间的相关性。总共检查了24例ABO不兼容的移植物的75例活检（55例，移植物功能障碍17例，其他适应症3例）和66例HLA不相容的移植物的244例活检（103例，移植物功能障碍129例，其他适应症12例）。 ;全部都染色为C4d，大约40％为C3d。在不兼容ABO的移植物中，80％的协议活检和59％的移植物功能异常进行了检查，结果显示肾小管周围毛细血管（PTC）中存在C4d染色;这种染色与PTC中的中性粒细胞边缘无关。在与HLA不相容的移植物中，PTC C4d存在于26％的方案活检和60％的活检中。 92％的活检> 1+（0-4 +比例），弥漫性PTC C4d的切缘和/或血栓性微血管病（TMA）大于或= 1 +，而C4d阴性的活检则为12％。在ABO不兼容但不是HLA不兼容的移植物中，C3d比C4d更能预测边缘化。总之，尽管PTC C4d沉积表明在HLA不相容移植物的活检中（包括方案活检）可能存在AMR，但没有组织学证据表明C4d沉积与大多数ABO不相容移植物中的损伤相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号