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DNA-abzymes in rheumatoid arthritis: pathogenetic and clinical significance

机译：类风湿性关节炎中的DNA - 厌恶：致病性和临床意义

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摘要

AIM: To study possible pathogenetic role and clinical significance of DNA-hydrolysing autoantibodies (autoAB) or DNA-abzymes in patients with rheumatoid arthritis. MATERIAL AND METHODS: Prevalence of DNA-abzymes and their catalytic activity were studied in 400 patients with rheumatoid arthritis (RA) and 88 healthy donors matched by age and gender. RESULTS: Associated with DNA-binding autoAB DNA-hydrolysing activity was detected in 41.5% cases of RA. DNA-abzymes were maximally active in men with rheumatoid factor (RF) and women without RF, while it was minimal in men without RF and women with RF. By catalytic activity there was no significant differences between patients with RF and without it. The highest catalytic activity of DNA abzymes was detected in patients with distinct extraarticular pathology. DNA-abzymes were also active in patients with x-ray stage III-IV of the disease in association with high prevalence of catalytic autoAB. DNA abzymes were also active in patients with RA activity stage II and III. CONCLUSION: It is possible to use DNA-abzymes in clinical practice for monitoring of the disease activity in RA.
机译：目的：研究DNA水解自身抗体（AutoAB）或DNA - 厌卵虫在类风湿性关节炎患者中的可能致病作用和临床意义。物质和方法：在400例类风湿性关节炎（RA）和88名受年龄和性别匹配的健康捐赠者中，研究了DNA-厌恶患者的患病率及其催化活性。结果：在41.5％Ra病例中检测到DNA结合的AutoAB DNA水解活性。 DNA-厌恶的男性在具有类风湿因子（RF）和没有RF的女性的男性中最大活跃，而没有RF和患有RF的妇女的男性在最小。通过催化活性，RF患者与没有它的患者之间没有显着差异。在患有明显的特殊病理学的患者中检测到DNA厌恶的最高催化活性。 DNA - 戒烟中也活跃于患有催化自身吸引的高患病率的X射线阶段III-IV患者。 DNA厌恶也活跃于RA活性阶段II和III患者。结论：可以在临床实践中使用DNA - 厌恶，用于监测RA中的疾病活性。

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