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首页> 外文期刊>Biomaterials >Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP
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Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP

机译：含有干细胞归巢因子SDF-1和血管生成肽AC-SDKP的可注射水凝胶再生慢性心肌梗死的再生

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摘要

Regeneration of chronic myocardial infarction (CMI) is one of the challenging issues due to its limited regeneration activity compared to acute or sub-acute stage. In this study, we examined whether combination of stem cell homing factor (SDF-1) and angiogenic peptides (Ac-SDKP) injected with biomimetic hydrogels promote regeneration of cardiac function in a CMI model. We evaluated the regeneration of chronically infarcted myocardium using injectable biomimetic hydrogels containing two therapeutic factors; stromal-derived factor-1 (SDF-1) and Ac-SDKP for stem cell homing and angiogenesis, respectively. Injection of the two therapeutic factors into the infarct region of the left ventricle showed that the biomimetic hydrogels containing two therapeutic factor exhibited significantly improved left ventricle function, increased angiogenesis, decreased infarct size and greatest wall thickness within the infarct region at 4 weeks post-treatment. From these results, it is clear that hydrogels containing two therapeutic factors showed synergistic effects on regeneration in the chronic heart failure model. In conclusion, these results suggest that combination of stem cell homing factor with angiogenic peptides recruit stem cells to the microenvironments, increase the expression of angiogenic genes, enhance the matured vessel formation and improve the cardiac function in chronic MI.
机译：慢性心肌梗死的再生（CMI）是与急性或亚急性阶段相比其有限的再生活性引起的具有挑战性问题之一。在该研究中，我们检查了用仿生水凝胶注入的干细胞归巢因子（SDF-1）和血管生成肽（AC-SDKP）的组合促进CMI模型中的心脏功能再生。我们使用含有两种治疗因素的可注射的仿生水凝胶评估了慢性梗塞心肌的再生;基质衍生因子-1（SDF-1）和用于干细胞归巢和血管生成的AC-SDKP。将两种治疗因素注射到左心室的梗死区，表明，含有两种治疗因子的仿生水凝胶显着提高了左心室功能显着改善，血管生成增加，在治疗后4周，梗塞区域内的梗死区减少，梗塞区域下降。 。从这些结果来看，显然含有两种治疗因子的水凝胶对慢性心力衰竭模型中的再生表现出协同作用。总之，这些结果表明，干细胞归巢因子与血管生成肽的组合募集到微环境中的干细胞，增加血管生成基因的表达，增强了成熟的容器形成并改善慢性Mi中的心脏功能。

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  • 来源
    《Biomaterials》 |2014年第8期|共10页
  • 作者

    SongM.; JangH.; LeeJ.; KimJ.H.; KimS.H.; SunK.; ParkY.;

  • 作者单位

    Korea Artificial Organ Center Korea University Seoul 136-705 South Korea;

    Korea Artificial Organ Center Korea University Seoul 136-705 South Korea Department of;

    Korea Artificial Organ Center Korea University Seoul 136-705 South Korea;

    Biomaterials Research Center Korea Institute of Science and Technology Seoul 136-791 South Korea;

    Biomaterials Research Center Korea Institute of Science and Technology Seoul 136-791 South Korea;

    Department of Biomedical Engineering College of Medicine Korea University Seoul 136-705 South;

    Korea Artificial Organ Center Korea University Seoul 136-705 South Korea Department of;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    Ac-SDKP; Chronic heart failure; Controlled release system; Hydrogel; Matrix metalloproteinase (MMP); SDF-1;

    机译：AC-SDKP;慢性心力衰竭;控释系统;水凝胶;基质金属蛋白酶（MMP）;SDF-1;

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